Polymicrobial prosthetic joint infections: risk factors and outcome.

Clinical Orthopaedics and Related Research
Camelia E Marculescu, J Robert Cantey

Abstract

Limited data are available regarding the risk factors and outcome of polymicrobial prosthetic joint infection (PJIs) when compared with monomicrobial PJI. Between January 1998 and November 2006, we retrospectively identified 34 of 174 prosthetic joint infections (19%) were polymicrobial. The 2-year cumulative probability of success of treating polymicrobial and monomicrobial PJIs was 63.8% and 72.8%, respectively. Twenty-six percent, 38%, and 29% of PJIs were treated with two-stage exchange, débridement and retention, or resection arthroplasty, respectively, and the 2-year survival rate free of treatment failure in each group was 77.7% (95% confidence interval, 42.8%-94.2%), 52.7% (95% confidence interval, 28.4%-75.9%), and 64.2% (95% confidence interval, 28.7%-88.9%). Methicillin-resistant Staphylococcus aureus (26.4% versus 7.1%) and anaerobes (11.7% versus 2.8%) were more common in polymicrobial PJIs. Polymicrobial PJIs occurred in patients with a soft tissue defect/dehiscence (23.5% versus 2.8%), drainage (79.4% versus 39.2%), or prior local irradiation (8.8% versus 0.71%). We found the following factors associated with polymicrobial prosthetic joint infections: the presence of a soft tissue defect/wound dehiscence (odds ra...Continue Reading

References

Apr 1, 1996·The Journal of Bone and Joint Surgery. American Volume·D T TsukayamaR B Gustilo
Aug 1, 1997·Annals of the Rheumatic Diseases·C J KaandorpB A Dijkmans
Mar 11, 1998·The Journal of Arthroplasty·K HirakawaM Secic
Nov 25, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E F BerbariD R Osmon
Dec 29, 2000·Clinical Orthopaedics and Related Research·W O Jackson, T P Schmalzried
Jan 24, 2003·The Journal of Bone and Joint Surgery. American Volume·Dean T TsukayamaRichard Kyle
Apr 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph R Lentino
Jun 6, 2003·Best Practice & Research. Clinical Rheumatology·Lars LidgrenAnna Stefánsdóttir
Jun 16, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Tan S L EzekialRupert F Snyman
Aug 20, 2005·Journal of the American Geriatrics Society·Florence GavetJean Jacques Dubost
May 31, 2007·Clinical Orthopaedics and Related Research·Cassandra D SalgadoCamelia E Marculescu

❮ Previous
Next ❯

Citations

Aug 21, 2009·The New England Journal of Medicine·Jose L Del Pozo, Robin Patel
Mar 28, 2013·Indian Journal of Orthopaedics·Vinay K AggarwalJavad Parvizi
Nov 14, 2013·TheScientificWorldJournal·D S EvangelopoulosJ Vlamis
Jun 12, 2013·Orthopedics·John R FowlerAsif M Ilyas
Jul 4, 2015·International Orthopaedics·Ari-Pekka PuhtoHannu Syrjälä
Jul 2, 2016·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Dragan RadoicicDanica Radoicic
Oct 21, 2016·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Svetlana BozhkovaAnna Rukina
Mar 9, 2017·Acta Orthopaedica·Ellen GurenMarianne Westberg
Dec 22, 2016·The Journal of Bone and Joint Surgery. American Volume·Timothy L TanJavad Parvizi
Dec 21, 2016·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Heng LiJiying Chen
Apr 4, 2014·Clinical Microbiology Reviews·Aaron J Tande, Robin Patel
Oct 1, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gladius Lewis
Dec 23, 2010·Drugs & Aging·Emily K Shuman, Preeti N Malani
Nov 28, 2015·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·P MassinJ Y Jenny
Nov 20, 2009·Scandinavian Journal of Infectious Diseases·Anna StefánsdóttirOtto Robertsson
Sep 22, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ashley C ParkerWarren O Haggard
May 4, 2012·Clinical Orthopaedics and Related Research·Mohammad R RasouliJavad Parvizi
Jul 18, 2018·Journal of Bone and Joint Infection·Ricardo Sousa, Miguel Araújo Abreu
May 23, 2017·Journal of Bone and Joint Infection·Neel B ShahElie F Berbari
May 26, 2017·Journal of Bone and Joint Infection·Neel ShahElie F Berbari
Jan 13, 2015·Expert Review of Anti-infective Therapy·Dolors Rodríguez-PardoBenito Almirante
Jul 15, 2020·Knee Surgery & Related Research·Du-Han KimByung-Chan Choi
Nov 20, 2016·International Orthopaedics·Nikolai M KliushinTatiana A Malkova
Jul 12, 2017·Infectious Diseases·Martin Lindberg-LarsenJens Bagger
Mar 29, 2011·Hospital Practice·William R Howell, Claudia Goulston
Feb 7, 2017·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Carl MellnerSebastian Mukka
Nov 7, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ray K SaundersChristopher S Adams
Mar 20, 2019·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Alejandro Lizaur-UtrillaFernando A Lopez-Prats
May 24, 2019·Journal of Orthopaedic Surgery·Yifang TsaiYuhan Chang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Elie F BerbariDouglas R Osmon
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Eric SennevilleHenri Migaud
© 2022 Meta ULC. All rights reserved