Polymicrobial pulmonary infection in patients with hematological malignancies: prevalence, co-pathogens, course and outcome

Infection
Emilia HardakIlana Oren

Abstract

The frequency and clinical significance of polymicrobial pneumonia in patients with hematological malignancies (HM) are poorly understood. The aim of the present study is to describe the prevalence, risk factors, clinical characteristics, and outcome of patients with HM and polymicrobial pneumonia. Over a 5 year period, 436 consecutive adult patients with HM and pulmonary infiltrates underwent diagnostic fiberoptic bronchoscopy with bronchoalveolar lavage. For 219 patients an infectious etiology was diagnosed, of them 45 (20.5 %) had polymicrobial etiology. Risk factors, clinical course and outcome of polymicrobial pulmonary infection in patients with HM were established. 45 patients with HM were identified with polymicrobial pulmonary infection, 39 of them with two pathogens, and 6 with three. The most common co-pathogen identified was Aspergillus sp. (87 %). Allogeneic hematopoietic stem cell transplantation (HSCT) and graft versus host disease (GVHD) were predictors of polymicrobial infection. Compared to patients with monomicrobial pneumonia, patients with polymicrobialpulmonary infection had a more severe clinical course with more dyspnea (69 vs. 49 %, P = 0.016), hemoptysis (16 vs. 7 %, P = 0.065) and more required respir...Continue Reading

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Citations

Dec 21, 2019·BMC Pulmonary Medicine·Jiahui WangJing Feng
Sep 10, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Cristina Gamila Wakfie-CoriehJosé Luis Carreras Delgado
Apr 7, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Daniel J LachantRobert M Kottmann
Aug 12, 2020·Antimicrobial Agents and Chemotherapy·Elizabeth M Adamowicz, William R Harcombe
Feb 16, 2021·Frontiers in Cellular and Infection Microbiology·Yi-Yi QianJing-Wen Ai
Mar 5, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·François DanionUNKNOWN Collaborators
Aug 28, 2021·Antibiotics·Maxence RouyerSylvain Diamantis

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