Polymicrogyria in a fetus with human parvovirus B19 infection: a case with radiologic-pathologic correlation

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
J CourtierO A Glenn

Abstract

We report the prenatal magnetic resonance imaging (MRI) appearance of polymicrogyria with pathologic correlation in a fetus with congenital parvovirus B19 infection. Prenatal ultrasound revealed non-immune hydrops, but detected no fetal brain abnormalities. A subsequent fetal MRI scan performed at 23 weeks' gestation demonstrated bilateral polymicrogyria, which was confirmed at autopsy. To our knowledge, prenatal diagnosis of polymicrogyria in association with congenital parvovirus B19 infection has not been previously described. This case provides further evidence for brain abnormalities resulting from congenital parvovirus B19 infection, and suggests that fetal neuroimaging with MRI would be of value in suspected cases of congenital parvovirus infection.

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Citations

Feb 18, 2016·Birth Defects Research. Part A, Clinical and Molecular Teratology·Robert SmigielHirotomo Saitsu
Jul 14, 2016·Brain & Development·Phedias DiamandisPatrick Shannon
Sep 28, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Dimitra KappouAthena P Souka
Nov 1, 2016·Archives of Pathology & Laboratory Medicine·Peter ŠtrafelaMara Popović
Apr 12, 2017·Birth Defects Research·Asher Ornoy, Zivanit Ergaz
Feb 11, 2015·Advances in Anatomic Pathology·Ona M Faye-Petersen, Debra S Heller
Nov 26, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·T Vipotnik VesnaverM Popović

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