PMID: 1136858Apr 1, 1975

Polymorphic acetylation of procaine amide in healthy subjects

Acta Medica Scandinavica
E Karlsson, L Molin

Abstract

The acetylation of procaine amide has been studied by means of gas liquid chromatography in 33 healthy human volunteers. The acetylator phenotype was determined by measuring unchanged and acetylated sulphapyridine in urine. Slow acetylators of sulphapyridine excreted significantly less procaine amide in acetylated from in the urine than rapid acetylators (9 plus or minus 1% against 19 plus or minus 4%). Hence, it is suggested that the acetylation of procaine amide is subject to the same genetic polymorphism as that of isoniazid and some sulfonamides.

References

Nov 1, 1973·Clinical Pharmacology and Therapeutics·M M ReidenbergC T Bello
Jun 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·D E DrayerR W Sevy
Dec 4, 1969·The New England Journal of Medicine·J Koch-WeserR W DeSanctis
Jun 1, 1972·Journal of Medical Genetics·H Schröder, D A Evans
Dec 1, 1974·British Journal of Clinical Pharmacology·E KarlssonF Sjöqvist

Citations

Feb 19, 1979·European Journal of Clinical Pharmacology·P SchröderE Simonsen
Mar 1, 1990·Arthritis and Rheumatism·W Zacharias, W J Koopman
Nov 1, 1991·Biopharmaceutics & Drug Disposition·J D CoyleJ J Lima
Jan 1, 1981·Scandinavian Journal of Rheumatology·I LedenE Wàhlin-Boll
Jan 1, 1980·Scandinavian Journal of Urology and Nephrology·H WolfG T Bryan
Jan 1, 1976·Acta Medica Scandinavica·I StrandbergF Sjöqvist
Mar 22, 1976·European Journal of Clinical Pharmacology·K FrislidP K Lunde
Feb 1, 1982·British Journal of Clinical Pharmacology·H Olsen, J Mørland
May 17, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Stephen C Mitchell
Jan 1, 1977·Acta Medica Scandinavica·R LarssonL Molin
Jan 1, 1983·European Journal of Clinical Pharmacology·P YlitaloT Metsä-Ketelä

Related Concepts

Acetylation
Half-Life
Genetic Polymorphism
Rhythmin
Sulfapyridine

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