PMID: 6974957Jan 1, 1981Paper

Polymorphic acetylator phenotype and systemic lupus erythematosus

Acta Medica Scandinavica
E JohanssonM J Mattila

Abstract

Out of 69 patients with spontaneous systemic lupus erythematosus (SLE), phenotyped for polymorphic acetylation with sulphadimidine, 52 (75%) were slow acetylators. In the subgroup of SLE patients with chronic biologically false positive seroreactions for syphilis the percentage of slow acetylators was even higher, 88%. In the majority of the slow acetylators the disease had started later and had followed a milder course than in rapid acetylators. Cutaneous reactions suspected to be drug-induced were seen in 19 (17 slow acetylators) during an observation period of 3--7 years. The reactions were mostly of exanthematous or urticarial type but also fixed type of eruption was seen. Provocation tests with the suspected drug were performed in 14 patients. In 5 cases it could be demonstrated that the eruption was caused by the drug. The predominance of slow acetylators among our patients with spontaneous SLE was the same as has been observed in drug-induced SLE. This suggests a similar genetic background.

References

Sep 1, 1977·Clinical Pharmacology and Therapeutics·D E Drayer, M M Reidenberg
Aug 1, 1975·Seminars in Arthritis and Rheumatism·S L Lee, P H CHase
Apr 1, 1977·Arthritis and Rheumatism·B FoadE V Hess
Mar 1, 1978·Arthritis and Rheumatism·J VansantJ S Sergent
Jan 1, 1976·Drugs·D Alarcón-Segovia
Jan 1, 1977·Acta Medica Scandinavica·R LarssonL Molin
Mar 1, 1972·Journal of Medical Genetics·D A EvansJ M Vetters
May 1, 1980·Arthritis and Rheumatism·M M ReidenbergW C Robbins

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Citations

May 13, 2009·Lupus·C KiyoharaUNKNOWN Kyushu Sapporo SLE (KYSS) Study Group
Jan 1, 1986·Springer Seminars in Immunopathology·M B Stevens
Jan 24, 1985·The New England Journal of Medicine·R E Bernstein

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