PMID: 8964894Apr 1, 1996Paper

Polymorphic amino acid domains of the HLA-DQ molecule are associated with disease heterogeneity in myasthenia gravis

Journal of Neuroimmunology
P HjelmströmC B Sanjeevi

Abstract

The association between myasthenia gravis (MG) and polymorphic amino acid domains in the HLA-DQ molecule was studied in 79 Swedish patients and 155 unrelated, population-based controls. A domain unique for DQB1*0201 was positively associated in MG patients with thymic hyperplasia or an early disease onset, and two domains with residues common to DQA1*01 alleles or DQB1*05 and DQB1*06 alleles were negatively associated in patients with thymic hyperplasia or an early disease onset. Our results suggest that MG associated with thymic hyperplasia and thymoma differ in their HLA-DQ association and thus are likely to have different pathogenic mechanisms.

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Citations

Nov 5, 2003·Journal of Neuroimmunology·W L van der PolL H van den Berg
Sep 6, 2001·Journal of the Neurological Sciences·S SuzukiY Kawakami
Jul 31, 2001·Human Immunology·P W WirtzJ J Verschuuren
Feb 1, 1997·Tissue Antigens·P HjelmströmC B Sanjeevi
Aug 4, 1998·Journal of Neuroimmunology·P HjelmströmC B Sanjeevi
Feb 22, 2000·American Journal of Ophthalmology·M P Davey, J T Rosenbaum
Jan 13, 2005·Acta Neurologica Scandinavica·F RomiJ A Aarli
Nov 30, 2005·International Journal of Immunogenetics·S V GoverdhanW M Howell
Jan 19, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·P ChristadossC Deng
Apr 17, 2002·The Journal of Clinical Investigation·Huan YangPremkumar Christadoss
May 25, 2006·Human Immunology·Güher Saruhan-DireskeneliFeza Deymeer

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