Polymorphic functional imprinting of the human IGF2 gene among individuals, in blood cells, is associated with H19 expression

Biochemical and Biophysical Research Communications
N GiannoukakisC Polychronakos

Abstract

In most non-neoplastic tissues studied to date, IGF2 is expressed only from the paternal allele and H19 is expressed only from the maternal allele. The choroid plexus, the only normal tissue to date where IGF2 is expressed from both parental alleles, does not express H19. We present an additional situation in which biallelic IGF2 expression is associated with the absence of H19 transcription in normal tissue: blood cells. In blood cells, functional IGF2 imprinting was found to be a polymorphic trait among individuals: expression was biallelic in 79 out of 85 individuals, but the remaining 6 expressed a single allele. Only the latter expressed H19. Finally, the familial clustering of functional IGF2 imprinting in blood cells suggests that the trait may be genotype-dependent.

Citations

Nov 13, 2008·Nature Reviews. Genetics·Carole OberYoav Gilad
Oct 22, 2010·The Journal of Clinical Endocrinology and Metabolism·Liis UuskülaMaris Laan
Mar 4, 2000·Environmental Health Perspectives·S K Murphy, R L Jirtle
Sep 3, 2004·Genetics·Troy Day, Russell Bonduriansky
May 3, 2014·Cellular Reprogramming·Huseyin SumerPaul J Verma
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·L Carrel, H F Willard
May 11, 2002·Leukemia & Lymphoma·Walter Zumkeller
Feb 20, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·A VambergueJ Rousseaux
Feb 18, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·A HealdJ M Gibson
Mar 3, 2004·American Journal of Human Genetics·Emily L Niemitz, Andrew P Feinberg
Mar 18, 1999·The American Journal of Pathology·J G FallsR L Jirtle
Aug 12, 1999·American Journal of Human Genetics·C L Anderson, C J Brown
Jun 24, 2000·European Journal of Biochemistry·F WilkinC Mamelin
Mar 1, 1997·Molecular Reproduction and Development·L H LooijengaJ W Oosterhuis
Apr 30, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Sylvie CroteauAnna K Naumova
Mar 30, 2018·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Zhong Li, Yuanjie Niu
Feb 22, 2002·The Korean Journal of Internal Medicine·H S KimI K Lee
Jun 11, 1998·The Journal of Biological Chemistry·J PaquetteC Deal
Oct 24, 2018·Nature Genetics·Florian ZinkKari Stefansson
Jun 4, 1998·Current Opinion in Genetics & Development·W Reik, J Walter
Jul 10, 2021·Frontiers in Cell and Developmental Biology·Adam R PrickettRebecca J Oakey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Medical Genetics
I T ThomasM N Berry
International Journal of Epidemiology
Elizabeth Barrett-Connor
© 2021 Meta ULC. All rights reserved