Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes.

Breast Cancer Research and Treatment
Madhura S MehtaKim M Hirshfield

Abstract

TSC1 acts coordinately with TSC2 in a complex to inhibit mTOR, an emerging therapeutic target and known promoter of cell growth and cell cycle progression. Perturbation of the mTOR pathway, through abnormal expression or function of pathway genes, could lead to tumorigenesis. TSC1 and TSC2 expression is reduced in invasive breast cancer as compared with normal mammary epithelium. Because single nucleotide polymorphisms (SNPs) in regulatory genes have been implicated in risk and age at diagnosis of breast cancers, systematic SNP association studies were performed on TSC1 and TSC2 SNPs for their associations with clinical features of breast cancer. TSC1 and TSC2 haplotypes were constructed from genotyping of multiple loci in both genes in healthy volunteers. SNPs were selected for further study using a bioinformatics approach based on SNP associations with drug response in NCI-60 cell lines and evidence of selection bias based on haplotype frequencies. Genotyping for five TSC1 and one TSC2 loci were performed on genomic DNA from 1,137 women with breast cancer. This study found that for TSC1 rs7874234, TT variant carriers had a 9-year later age at diagnosis of estrogen receptor positive (ER+), but not ER-, ductal carcinomas (P = 0...Continue Reading

References

Feb 25, 1999·The Australian and New Zealand Journal of Surgery·I C BennettB T Teh
Jul 14, 2001·Nucleic Acids Research·C M Klinge
Mar 21, 2002·The Lancet Oncology·T J KeyE Banks
Aug 18, 2004·Genes & Development·Nissim Hay, Nahum Sonenberg
Apr 27, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Brian YorkDaniel J Noonan
Jun 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Zhaohui FengShengkan Jin
Jan 25, 2006·Saudi Medical Journal·Layla J Al-Mansouri, Majed S Alokail
Feb 3, 2006·Annals of Neurology·David Neal FranzKerry R Crone
Apr 25, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Miguel Martín
Jul 17, 2007·Trends in Molecular Medicine·Petrus J de Vries, Christopher J Howe
May 10, 2008·The Biochemical Journal·Jingxiang Huang, Brendan D Manning
Jun 12, 2008·Annual Review of Genomics and Human Genetics·Clare Turnbull, Nazneen Rahman
Jun 12, 2008·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Philippe BertheauHugues de Thé
Dec 2, 2008·Nature Reviews. Drug Discovery·Alexei VazquezGareth L Bond
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Veronica Wendy SetiawanSara H Olson
Jan 16, 2009·Biochemical Society Transactions·Julian R Sampson
Feb 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jane J YuElizabeth P Henske
Apr 1, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Funda Meric-Bernstam, Ana Maria Gonzalez-Angulo
May 6, 2009·International Journal of Cancer. Journal International Du Cancer·Suleeporn SangrajrangTeruhiko Yoshida
Feb 12, 2010·Annals of the New York Academy of Sciences·Ksenia A Orlova, Peter B Crino
Mar 20, 2010·Cellular and Molecular Life Sciences : CMLS·D Joseph JerryMary J Hagen

❮ Previous
Next ❯

Citations

Nov 19, 2015·Carcinogenesis·Ting-Yuan David ChengLynn Rosenberg
Dec 17, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S MasA Lafuente
May 18, 2016·International Journal of Molecular Sciences·Simona GranataGianluigi Zaza
Jan 9, 2019·Journal of Molecular Endocrinology·Ayse Basak EnginIpek Isik Gonul
Dec 1, 2018·BMC Bioinformatics·Antonino FiannacaAlfonso Urso
Feb 13, 2021·Molecular and Cellular Biochemistry·Karthik Mallela, Arun Kumar
Feb 25, 2021·Pharmacogenomics and Personalized Medicine·Kangjian SongLiqun Wu
Nov 24, 2020·Current Cancer Drug Targets·Irina R GilyazovaGjumrakch Aliev

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.