Polymorphic variants of extracellular superoxide dismutase gene in a Romanian population with atheroma

Biochemical Genetics
Olguta C SamoilaEdward Seclaman

Abstract

Extracellular superoxide dismutase (EC-SOD) is the main SOD isoform in the arterial wall contributing to cardiovascular defense against oxidative stress by removing the superoxide anion. In our study, the Thr40Ala and Arg213Gly polymorphic variants of the EC-SOD gene (SOD ( 3 )) were investigated for associations with atherosclerosis and other related factors in 144 subjects with significant atheroma (having one, two, or three major coronary arteries with >50% obstruction, and/or peripheral artery lesions, and/or carotid artery stenosis demonstrated by angiography and echography) and in 150 subjects with no significant atheroma. For the Arg213Gly polymorphism, only five heterozygous subjects were found. Although the difference in the genotype distribution for the Thr40Ala polymorphism was not statistically significant between patients with atheroma (AA 49.3%, AG 34.7%, GG 16.0%) and those without significant atheroma (AA 41.3%, AG 43.3%, GG 15.3%), there was an association of the Thr40 allele with diabetes (P = 0.03) and hypertension (P = 0.04).

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Citations

Sep 30, 2014·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Chao-xian ZhangLi-ke Guo
Mar 13, 2012·International Journal of Molecular Sciences·Cleva Villanueva, Robert D Kross
May 24, 2012·Current Opinion in Lipidology·Xiangdong WuKevin Jon Williams
Jun 20, 2014·Experimental and Therapeutic Medicine·Xiaolong DongYanyan Zhao
Mar 17, 2020·Atherosclerosis·Xiangdong WuKevin Jon Williams

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