Abstract
Extracellular superoxide dismutase (EC-SOD) is the main SOD isoform in the arterial wall contributing to cardiovascular defense against oxidative stress by removing the superoxide anion. In our study, the Thr40Ala and Arg213Gly polymorphic variants of the EC-SOD gene (SOD ( 3 )) were investigated for associations with atherosclerosis and other related factors in 144 subjects with significant atheroma (having one, two, or three major coronary arteries with >50% obstruction, and/or peripheral artery lesions, and/or carotid artery stenosis demonstrated by angiography and echography) and in 150 subjects with no significant atheroma. For the Arg213Gly polymorphism, only five heterozygous subjects were found. Although the difference in the genotype distribution for the Thr40Ala polymorphism was not statistically significant between patients with atheroma (AA 49.3%, AG 34.7%, GG 16.0%) and those without significant atheroma (AA 41.3%, AG 43.3%, GG 15.3%), there was an association of the Thr40 allele with diabetes (P = 0.03) and hypertension (P = 0.04).
References
Sep 15, 1984·The Biochemical Journal·S L Marklund
Oct 1, 1984·The Journal of Clinical Investigation·S L Marklund
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S L Marklund
Nov 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·P StrålinS L Marklund
Jun 1, 1995·The Japanese Journal of Human Genetics·H YamadaK Kato
Dec 1, 1994·Human Molecular Genetics·R J FolzJ D Crapo
Jul 1, 1994·Genomics·R J Folz, J D Crapo
Sep 15, 1993·The Biochemical Journal·J SandströmS L Marklund
Jan 1, 1996·Free Radical Biology & Medicine·T D OuryJ D Crapo
Jul 1, 1997·Journal of Internal Medicine·S L MarklundK Asplund
Jun 1, 1997·The Japanese Journal of Human Genetics·H YamadaS Kakumu
Mar 4, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·J S LuomaS Ylä-Herttuala
Sep 17, 1998·FEBS Letters·T Adachi, X L Wang
Oct 22, 1998·Human Pathology·N SakashitaK Takahashi
Jul 19, 2002·Cardiovascular Research·Tohru FukaiDavid G Harrison
Jul 20, 2002·Free Radical Biology & Medicine·Igor N ZelkoRodney J Folz
Jul 31, 2002·Biochemical and Biophysical Research Communications·Tomomi OokawaraHideki Ohno
Jul 30, 2003·Free Radical Biology & Medicine·Cheryl L FattmanTim D Oury
Dec 10, 2003·Circulation·Klaus JuulBørge G Nordestgaard
May 29, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Frank M Faraci, Sean P Didion
Aug 7, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·David SeoPascal J Goldschmidt-Clermont
May 3, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Steen V Petersen, Jan J Enghild
May 19, 2005·Mutation Research·Salvatore CampoAlberto Calatroni
Jul 2, 2005·Diabetes Research and Clinical Practice·Masanori TamaiKishio Nanjo
Citations
Jan 3, 2014·Antioxidants & Redox Signaling·Carlo Dani, Chiara Poggi
Mar 12, 2016·Atherosclerosis·Kevin Jon Williams, Xiangdong Wu
Mar 10, 2011·Journal of the Science of Food and Agriculture·Lin Yu-LingChou Su-Tze
May 12, 2012·Free Radical Research·Betti GiustiCarlo Dani
Sep 30, 2014·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Chao-xian ZhangLi-ke Guo
Mar 13, 2012·International Journal of Molecular Sciences·Cleva Villanueva, Robert D Kross
May 24, 2012·Current Opinion in Lipidology·Xiangdong WuKevin Jon Williams
Jun 20, 2014·Experimental and Therapeutic Medicine·Xiaolong DongYanyan Zhao
Feb 9, 2020·Heart and Vessels·Nisa DecharatchakulKittisak Sawanyawisuth
Mar 17, 2020·Atherosclerosis·Xiangdong WuKevin Jon Williams