Polymorphic variants of genes involved in choline pathway and the risk of intrauterine fetal death

Ginekologia polska
Krzysztof DrewsAgnieszka Seremak-Mrozikiewicz

Abstract

Choline and folate metabolism disturbances may be involved in the occurrence of intrauterine fetal death (IUFD). The proper activity of this metabolism could be determined by genetic variants involved in choline pathway e.g. CHKA (gene encoding choline kinase α), PCYT1A (gene encoding CCTα) and CHDH (gene encoding choline dehydrogenase). Our study aimed at determining the genotype and allele frequencies of CHKA rs7928739, PCYT1A rs712012, PCYT1A rs7639752, CHDH rs893363 and CHDH rs2289205 polymorphisms in mothers with IUFD occurrence. The study involved 76 mothers with IUFD occurrence and 215 mothers of healthy children. Genetic analysis was performed with the use of PCR/RFLP method. The frequency of genotypes and alleles of studied polymorphisms was similar in both groups. The study revealed no association of PCYT1A, CHKA and CHDH polymorphisms in analysed groups of women. While evaluating the co-existence of analysed polymorphisms statistically significant correlation was revealed. Co-existence of CHKA rs7928739 AC/CHDH rs2289205 AA genotypes was observed statistically more frequently in the study group than in the control group (p = 0,031). There is no correlation between single CHKA rs7928739, PCYT1A rs712012, PCYT1A rs7639...Continue Reading

Citations

May 3, 2019·Nutrition & Dietetics : the Journal of the Dietitians Association of Australia·Agata ChmurzynskaKrzysztof Drews
Jun 26, 2020·Eye and Vision·Ce ShiHong Jiang

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