Polymorphic variation in the dopamine D4 receptor predicts delay discounting as a function of childhood socioeconomic status: evidence for differential susceptibility.

Social Cognitive and Affective Neuroscience
Maggie M SweitzerStephen B Manuck

Abstract

Inconsistent or null findings among studies associating behaviors on the externalizing spectrum--addictions, impulsivity, risk-taking, novelty-seeking traits--with presence of the 7-repeat allele of a common length polymorphism in the gene encoding the dopamine D4 receptor (DRD4) may stem from individuals' variable exposures to prominent environmental moderators (gene × environment interaction). Here, we report that relative preference for immediate, smaller rewards over larger rewards delayed in time (delay discounting), a behavioral endophenotype of impulsive decision-making, varied by interaction of DRD4 genotype with childhood socioeconomic status (SES) among 546 mid-life community volunteers. Independent of age, sex, adulthood SES and IQ, participants who were both raised in families of distinctly low SES (low parental education and occupational grade) and carried the DRD4 7-repeat allele discounted future rewards more steeply than like-reared counterparts of alternate DRD4 genotype. In the absence of childhood socioeconomic disadvantage, however, participants carrying the 7-repeat allele discounted future rewards less steeply. This bidirectional association of DRD4 genotype with temporal discounting, conditioned by partic...Continue Reading

References

Jun 1, 1993·Human Molecular Genetics·J B LichterK J Livak
Apr 30, 1999·Journal of the Experimental Analysis of Behavior·J B RichardsH de Wit
Nov 7, 1999·Psychopharmacology·S H Mitchell
Feb 2, 2000·Neuroscience and Biobehavioral Reviews·J M SwansonM Posner
Jun 3, 2000·Genetics·J K PritchardP Donnelly
Oct 18, 2000·European Journal of Pharmacology·J N OakH H Van Tol
Sep 13, 2001·Clinical Genetics·D E ComingsR J Rosenthal
Feb 28, 2002·Journal of Abnormal Psychology·Kent E HutchisonAndrew Smolen
Jul 4, 2002·Journal of Personality·Edelgard WulfertMelissa Colsman
Aug 23, 2002·Molecular Psychiatry·A N KlugerR P Ebstein
Sep 5, 2002·American Journal of Medical Genetics·J A SchinkaF C Crawford
Mar 8, 2003·Experimental and Clinical Psychopharmacology·Scott F CoffeyKathleen T Brady
Jul 2, 2003·Addictive Behaviors·Scott H Kollins
Oct 22, 2003·Molecular Psychiatry·L Keltikangas-JärvinenL Peltonen
Oct 29, 2003·The Pharmacogenomics Journal·O Schoots, H H M Van Tol
Jan 28, 2004·Behavioural Processes·Brady ReynoldsKatherine Karraker
Apr 13, 2004·American Journal of Human Genetics·E WangR K Moyzis
May 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kehong ZhangRoss J Baldessarini
Jul 16, 2004·Proceedings. Biological Sciences·Margo Wilson, Martin Daly
Sep 16, 2004·Psychological Bulletin·Leonard Green, Joel Myerson
Oct 16, 2004·Science·Samuel M McClureJonathan D Cohen
Apr 22, 2005·Journal of the American Academy of Child and Adolescent Psychiatry·Manfred LauchtMartin H Schmidt
May 24, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Mark A BellgroveMichael Gill
Jul 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stan B FlorescoMaric T L Tse
Jun 3, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Russell A BarkleyBradford Navia
Jun 20, 2006·Biological Psychiatry·Christian KielingLuis Augusto Rohde
Nov 1, 1995·Journal of the Experimental Analysis of Behavior·J Myerson, L Green

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Citations

Dec 20, 2012·Current Psychiatry Reports·Ryan W CarpenterDorret I Boomsma
May 22, 2013·Neuropharmacology·N D Volkow, R D Baler
Jan 11, 2014·Annual Review of Psychology·Stephen B Manuck, Jeanne M McCaffery
Mar 2, 2016·Alcoholism, Clinical and Experimental Research·Frances L WangKevin King
Sep 24, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·W Thomas Boyce
Apr 3, 2016·Neuroscience Bulletin·Guorong MaWei Wang
Jan 1, 2015·Journal of HIV/AIDS & Social Services·Jessica M SalesRalph J DiClemente
Aug 26, 2014·Annual Review of Psychology·Marian J Bakermans-Kranenburg, Marinus H van IJzendoorn
Jun 16, 2017·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Amanda N NoroñaBruce L Baker
Feb 3, 2015·Development and Psychopathology·Marinus H van Ijzendoorn, Marian J Bakermans-Kranenburg
May 23, 2014·International Psychogeriatrics·Joseph P BarsugliaMario F Mendez
Dec 18, 2013·Development and Psychopathology·Jay Belsky, Michael Pluess
Aug 21, 2013·Social Cognitive and Affective Neuroscience·Jan Van den StockBeatrice de Gelder
Mar 8, 2014·Social Cognitive and Affective Neuroscience·Jennifer A SilversKevin N Ochsner
May 20, 2014·Social Cognitive and Affective Neuroscience·Guillaume SescousseJean-Claude Dreher
May 1, 2014·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Mina Cikara, Jay J Van Bavel
Jun 25, 2014·Social Cognitive and Affective Neuroscience·Elizabeth Redcay, Thomas A Carlson
Aug 29, 2019·Development and Psychopathology·Gregory M Fosco, Emily J LoBraico
Jan 19, 2018·The Behavioral and Brain Sciences·James M Sherlock, Brendan P Zietsch
Dec 12, 2017·Psychiatry Journal·Christopher W T Miller
Jun 15, 2019·Applied Psychology. Health and Well-being·Yiqun GanLi Wang
Jan 12, 2017·The Behavioral and Brain Sciences·Gillian V Pepper, Daniel Nettle
May 17, 2017·Proceedings of the National Academy of Sciences of the United States of America·Martha J Farah, Cayce J Hook
May 4, 2021·Frontiers in Psychology·Kristof KeidelUlrich Ettinger
Jun 29, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Verònica Casadó-AngueraVicent Casadó
Mar 20, 2018·Appetite·Bradley M AppelhansLisa M Powell

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