Polymorphism and plasma levels of apolipoprotein E and the risk of aneurysmal subarachnoid hemorrhage in a Chinese population: a case-control study

Lipids in Health and Disease
Xiaofeng LiuQishui Ou

Abstract

Aneurysmal subarachnoid hemorrhage (aSAH) is the most common types of subarachnoid hemorrhage, which is a critical clinical problem with high morbidity, mortality, and economic impact. Recent studies have shown that APOE was a genetic risk factor of aSAH, however, the studies lack consistent conclusions and the evidence from Chinese Han population is rare. To determine the relationship between APOE polymorphism and the incidence of aSAH in Chinese Fujian Han population and explore the possible mechanism of ApoE in the pathogenesis of aSAH. A total of 131 patients newly diagnosed with aSAH were selected as aSAH group and 137 healthy subjects were selected as the control group. All the samples were analyzed for blood lipids and serum ApoE levels, and ApoE genotype was determined by a commercial chip and further confirmed with Sanger sequencing. An adjusted multivariate logistic regression analysis was carried out to estimate the effects of APOE polymorphism on the risk of aSAH. Compared with the controls, the serum TC, HDL-C and ApoA1 levels in aSAH were significantly lower: TC (4.52 ± 1.38 vs. 5.11 ± 0.86 mmol/L, P < 0.001), HDL-C (1.23 ± 0.46 vs. 1.44 ± 0.32 mmol/L, P < 0.001) and ApoA1 (1.20 ± 0.32 vs. 1.38 ± 0.25 g/L, P < 0.0...Continue Reading

References

Jul 1, 1994·Stroke; a Journal of Cerebral Circulation·J P BroderickA Leach
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Nov 10, 2001·Annual Review of Genomics and Human Genetics·R W Mahley, S C Rall
Apr 12, 2005·Mayo Clinic Proceedings·Eelco F M WijdicksDavid G Piepgras
Jun 15, 2005·Journal of Korean Medical Science·Min-Ho ShinJin-Su Choi
Jun 25, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yasuharu Tokuda, Gerald H Stein
Jul 22, 2005·Brain : a Journal of Neurology·G M TeasdaleJ A R Nicoll
Nov 12, 2005·Stroke; a Journal of Cerebral Circulation·Valery L FeiginCraig S Anderson
Apr 1, 2006·Stroke; a Journal of Cerebral Circulation·Youhei MineharuAkio Koizumi
May 2, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·N K de RooijG J E Rinkel
May 24, 2007·Cerebrovascular Diseases·Majed J KatatiVentura Arjona-Moron
Aug 4, 2007·BMC Medical Genetics·Ritesh KaushalRanjan Deka
Mar 14, 2012·Annals of Indian Academy of Neurology·Ashraf V ValappilA S Girija
Dec 12, 2012·Neuron·Robert W Mahley, Yadong Huang
Jan 9, 2013·Nature Reviews. Neurology·Chia-Chen LiuGuojun Bu
Nov 7, 2013·Stroke; a Journal of Cerebral Circulation·Trine H AndreasenBertil Romner
Sep 1, 2014·Neurobiology of Disease·Yadong Huang, Robert W Mahley
Sep 17, 2015·Acta Neurologica Scandinavica·L Z CsajbokB Nellgård
Apr 15, 2016·PloS One·Joni Valdemar LindbohmMiikka Korja
Jun 10, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Robert W Mahley
Sep 18, 2016·Lancet·R Loch Macdonald, Tom A Schweizer

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Citations

Mar 20, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Xiaodong YeSuiqiang Zhu

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Methods Mentioned

BETA
genotyping
chip
PCR

Software Mentioned

SPSS

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