Polymorphism and transcription at the p44-1/p44-18 genomic locus in Anaplasma phagocytophilum strains from diverse geographic regions

Infection and Immunity
Quan LinRichard C Falco

Abstract

A polymorphic multigene family (p44) of Anaplasma phagocytophilum encodes the immunodominant 44-kDa major outer membrane proteins. With p44-specific PCR and gene-specific probes, p44-1 was found in all human isolates from New York State but not in isolates from Minnesota, whereas p44-18 and two other p44 species were found in isolates from both regions. We therefore sequenced the genomic locus corresponding to the p44-1/p44-18 tandem locus of A. phagocytophilum HZ in 14 other geographically divergent strains from various hosts. The locus was found in all 14 strains, and p44-18 was conserved among all 13 United States isolates studied. In all nine northeastern strains, p44-1 was conserved. However, in three of the Minnesota strains and in one California strain, p44-1 was replaced at this genomic locus by the novel gene p44-61 (p44-61/18), whose hypervariable region (hv) was a chimera of p44-20hv and p44-23hv. The conserved base sequence within the hv region linked the two segments. In contrast, in the Old Sourhope strain isolated from sheep in the United Kingdom, only a single and distinct p44, p44-OS, was found in this locus. This suggests different rates of evolution of p44-1 and p44-18 at this locus and conservation of the lo...Continue Reading

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Citations

Jun 27, 2006·Vector Borne and Zoonotic Diseases·Vivien G DuganWilliam R Davidson
Jul 8, 2011·Clinical Microbiology Reviews·Yasuko Rikihisa
Dec 19, 2006·Journal of Bacteriology·Haibin HuangYasuko Rikihisa
Aug 17, 2011·Parasites & Vectors·Cornelia SilaghiKurt Pfister
Feb 17, 2006·PLoS Genetics·Julie C Dunning HotoppHervé Tettelin
Nov 23, 2006·Annals of the New York Academy of Sciences·Yasuko Rikihisa

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