Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes

BMC Genetics
Gerard A J MorrisJohn A Todd

Abstract

The aetiology of the autoimmune disease type 1 diabetes (T1D) involves many genetic and environmental factors. Evidence suggests that innate immune responses, including the action of interferons, may also play a role in the initiation and/or pathogenic process of autoimmunity. In the present report, we have adopted a linkage disequilibrium (LD) mapping approach to test for an association between T1D and three regions encompassing 13 interferon alpha (IFNA) genes, interferon omega-1 (IFNW1), interferon beta-1 (IFNB1), interferon gamma (IFNG) and the interferon consensus-sequence binding protein 1 (ICSBP1). We identified 238 variants, most, single nucleotide polymorphisms (SNPs), by sequencing IFNA, IFNB1, IFNW1 and ICSBP1, 98 of which where novel when compared to dbSNP build 124. We used polymorphisms identified in the SeattleSNP database for INFG. A set of tag SNPs was selected for each of the interferon and interferon-related genes to test for an association between T1D and this complex gene family. A total of 45 tag SNPs were selected and genotyped in a collection of 472 multiplex families. We have developed informative sets of SNPs for the interferon and interferon related genes. No statistical evidence of a major associatio...Continue Reading

References

Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·D H KonoA N Theofilopoulos
Jun 10, 1998·Cytokine & Growth Factor Reviews·H NguyenP M Pitha
Jul 3, 1998·Nucleic Acids Research·J K BonfieldR Staden
Oct 5, 2001·Nature Genetics·G C JohnsonJ A Todd
Jan 10, 2002·European Journal of Immunology·Asa C M JohanssonRikard Holmdahl
Dec 19, 2003·American Journal of Human Genetics·Christopher S CarlsonDeborah A Nickerson
Mar 19, 2004·Genes and Immunity·C E LoweD G Clayton
Jun 29, 2004·Diabetes·Bryan J BarrattJohn A Todd
Oct 14, 2004·Genetic Epidemiology·David ClaytonJason Cooper
Dec 21, 2004·Nucleic Acids Research·Luc J SminkNathan Goodman
Sep 28, 2005·Diabetes·Patrick ConcannonUNKNOWN Type 1 Diabetes Genetics Consortium
Apr 10, 2009·Bioinformatics·Ram PodichetiQunfeng Dong

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Citations

Nov 29, 2013·Journal of Experimental Botany·Nathalie KuhnSerge Delrot
Dec 21, 2006·Autoimmunity·Nikolai Petrovsky, Vladimir Brusic
Apr 29, 2016·Medicine·Ying-Hsien HuangHo-Chang Kuo

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

Stata
Staden
gbrowse

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