Polymorphism in maternal LRP8 gene is associated with fetal growth.

American Journal of Human Genetics
Lin WangXin Xu

Abstract

Fetal growth restriction (FGR) affects >200,000 pregnancies in the United States annually and is associated with increased perinatal mortality and morbidity, as well as poorer long-term health for infants with FGR compared with infants without FGR. FGR appears to be a complex trait, but the role of genetic factors in the development of FGR is largely unknown. We conducted a candidate-gene association study of birth weight and FGR in two independent study samples obtained at the Boston Medical Center. We first investigated the association between maternal genotypes of 68 single-nucleotide polymorphisms (SNPs) from 41 candidate genes and fetal growth in a sample of 204 black women selected for a previous study of preeclampsia, 92 of whom had preeclampsia (characterized by high blood pressure and the presence of protein in the urine). We found significant association between SNP rs2297660 in the LRP8 gene and birth weight. Subsequently, we replicated the association in a larger independent sample of 1,094 black women; similar association between LRP8 and FGR was observed in this sample. The "A" allele at rs2297660 was associated with a higher standardized birth weight and a lower risk of FGR. Under the additive genetic model, each...Continue Reading

References

Nov 1, 1990·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·N A Callan, F R Witter
Jun 1, 1990·American Journal of Obstetrics and Gynecology·R L GoldenbergR C Baker
Apr 1, 1986·Obstetrics and Gynecology·B M Sibai, G D Anderson
Jul 23, 1999·BMJ : British Medical Journal·A LucasT J Cole
Jan 12, 2002·JAMA : the Journal of the American Medical Association·Xiaobin WangXiping Xu
Feb 28, 2002·American Journal of Epidemiology·Britt ClaussonSven Cnattingius
Feb 25, 2003·Lancet·Lon R Cardon, Lyle J Palmer
Aug 12, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·James M RobertsUNKNOWN National Heart Lung and Blood Institute
Oct 11, 2003·Obstetrics and Gynecology·Michael B BrackenBrian P Leaderer
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Mar 24, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Eyal Y AntebyYaron Hamani
Mar 31, 2004·Nature Genetics·Matthew L FreedmanDavid Altshuler
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly

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Citations

Apr 1, 2011·Journal of Developmental Origins of Health and Disease·N MatobaX Wang
May 21, 2008·Lupus·J E Salmon, P G de Groot
Mar 20, 2012·Trends in Endocrinology and Metabolism : TEM·Patricia M Lenhart, Kathleen M Caron
May 26, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hironori NagasakaTakashi Miida
Sep 23, 2008·Metabolism: Clinical and Experimental·Johanne Tremblay, Pavel Hamet
May 17, 2008·Seminars in Perinatology·Nancy Hendrix, Vincenzo Berghella
Sep 11, 2007·Seminars in Perinatology·Claire Infante-Rivard
Sep 8, 2009·The Journal of Allergy and Clinical Immunology·Rajesh KumarXiaobin Wang
Feb 11, 2015·Scientific Reports·Laura KasakMaris Laan
May 4, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H WangG Wang
Oct 2, 2008·Lupus·R T UrbanusP G de Groot
Nov 17, 2017·Journal of Psychosomatic Obstetrics and Gynaecology·Pamela J SurkanXiaobin Wang
Sep 1, 2010·Pediatric Allergy, Immunology, and Pulmonology·Rajesh KumarXiaobin Wang
Dec 12, 2012·Molecular and Cellular Biochemistry·Shenqiang HuJiwen Wang
Nov 3, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ulrich Schweizer, Noelia Fradejas-Villar
Sep 10, 2020·British Journal of Pharmacology·Daolai ZhangZhigang Xu
Feb 17, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Kartikeya MakkerXiaobin Wang
Aug 24, 2021·American Journal of Hypertension·J LongN T Mueller

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