PMID: 8985781Oct 1, 1996Paper

Polymorphism in the cytochrome P450 2E1 gene and alcohol-induced disorders of human spermatogenesis

International Journal of Andrology
J PajarinenP J Karhunen

Abstract

The association between alcohol-induced disorders of human spermatogenesis and four restriction fragment polymorphisms (DraI, MspI, PstI and RsaI) of the cytochrome P450 2E1 gene was investigated in an autopsy study on 254 men. Acquaintances were interviewed and the mean daily alcohol consumption of the subjects was calculated on the basis of the interviews. Spermatogenesis score and testicular morphology were assessed by light-microscopy, and cytochrome 2E1 polymorphic genotypes were determined using the polymerase chain reaction. Of the 204 heavy-drinking men, 42 (20.6%) men had normal spermatogenesis (p < 0.001, compared to moderate drinkers). Partial spermatogenic arrest was observed in 76 (37.3%) men and complete spermatogenic arrest in 79 (38.7%) men (p < 0.001, compared to moderate drinkers), whereas seven men (3.4%) had Sertoli cell only syndrome. The overall allelic frequencies for the common and rare polymorphic alleles were 0.98 and 0.02 (MspI) and 0.99 and 0.01 (PstI and RsaI), respectively. No associations between heterozygosity in the MspI, PstI or RsaI loci, or the allelic frequencies of common and rare alleles, and disorders of spermatogenesis were observed. The allelic frequencies for the common and rare polymo...Continue Reading

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Citations

Apr 25, 2003·Experimental and Molecular Pathology·Tamiko KonishiYu-Jui Yvonne Wan
Jan 1, 2013·Asian Journal of Andrology·Sandro La VigneraAldo E Calogero
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Jan 18, 2018·Reproductive Biology and Endocrinology : RB&E·Andrea SansoneDaniele Gianfrilli

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