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Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population

Clinical Rheumatology

Jun 15, 2007

Petr NemecJindra Gatterova

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Abstract

Rheumatoid arthritis (RA) is a model of multigenic inflammatory disorder in which tumor necrosis factor-alpha (TNF-alpha) plays an important role. Genetic factors may be implicated in the susceptibility to disease initiation as well as in severity of disease course. Elevated levels of T...read more

Mentioned in this Paper

Health Status
Tumor Necrosis Factor-alpha
Restriction Fragment Length Polymorphism
Plain X-ray
Inflammatory Disorder
Polymerase Chain Reaction Analysis
Transcription Initiation
Severity of Illness Index
Promoter
Genetic Markers
Paper Details
References
  • References44
  • Citations12
12345
  • References44
  • Citations12
12

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Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population

Clinical Rheumatology

Jun 15, 2007

Petr NemecJindra Gatterova

PMID: 17562093

DOI: 10.1007/s10067-007-0653-7

Abstract

Rheumatoid arthritis (RA) is a model of multigenic inflammatory disorder in which tumor necrosis factor-alpha (TNF-alpha) plays an important role. Genetic factors may be implicated in the susceptibility to disease initiation as well as in severity of disease course. Elevated levels of T...read more

Mentioned in this Paper

Health Status
Tumor Necrosis Factor-alpha
Restriction Fragment Length Polymorphism
Plain X-ray
Inflammatory Disorder
Polymerase Chain Reaction Analysis
Transcription Initiation
Severity of Illness Index
Promoter
Genetic Markers

Feeds With Similar Papers

Genomic Techniques

Recent developments in genomics and further development of advanced post-genomic technologies, it will be possible to apply a more holistic analysis to genomic analysis. Discover the latest research in Genomic Techniques.

Immunogenetics of Rheumatoid Arthritis

Rheumatoid arthritis is an autoimmune disease for which over 100 genetic risk loci have been identified. Genes involved in T cell receptor signalling, the JAK-STAT signalling pathway, and NF-kB signalling are enriched. Find the latest research on the immunogenetics of rheumatoid arthritis here.

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Rheumatology International

Tumour necrosis factor a -308 promoter polymorphism in patients with rheumatoid arthritis(opens in new tab)

Rheumatology InternationalSeptember 4, 2007
Zahra RezaieyazdiFarnaz Mohajer
Paper Details
References
  • References44
  • Citations12
12345
  • References44
  • Citations12
12

Download from

Publisher
PubMed
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