Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype

Journal of Human Genetics
Taku MiyagawaK Tokunaga

Abstract

Essential hypersomnia (EHS) exhibits excessive daytime sleepiness without cataplexy and is associated with the HLA-DRB1*1501-DQB1*0602 haplotype, similar to narcolepsy with cataplexy. Single-nucleotide polymorphism (SNP) rs1154155 located in the T-cell receptor alpha (TCRA) locus has been recently identified as a novel genetic marker of susceptibility for narcolepsy with cataplexy. We investigated whether the SNP was associated with EHS in the Japanese population. We found a significant association with EHS patients possessing the HLA-DRB1*1501-DQB1*0602 haplotype, compared with HLA-matched healthy individuals (P(allele)=0.008; P(positivity)=5 x 10(-4)), whereas no significant association was observed for EHS patients without this haplotype. Thus, TCRA is a plausible candidate for susceptibility to EHS patients positive for the HLA-DRB1*1501-DQB1*0602 haplotype.

References

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Feb 17, 2001·American Journal of Human Genetics·E MignotN Risch
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Sep 30, 2008·Nature Genetics·Taku MiyagawaKatsushi Tokunaga
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Citations

Mar 6, 2013·PLoS Genetics·Juliette FaracoEmmanuel Mignot
May 22, 2013·Journal of Diabetes Research·Brian G PierceJohn P Mordes
Nov 26, 2015·Sleep Medicine Reviews·Michel Billiard, Karel Sonka
Oct 26, 2013·Sleep Medicine·Yun-Hsiang ChenChia-Hsiang Chen
Oct 26, 2016·Journal of Human Genetics·Maria YamasakiKatsushi Tokunaga
Jun 30, 2010·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Flávio AlóeStella Márcia Azevedo Tavares
Sep 30, 2018·Journal of Human Genetics·Taku MiyagawaKatsushi Tokunaga

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