PMID: 10369Oct 1, 1976

Polymorphism of disopyramide

The Journal of Pharmacy and Pharmacology
S R GunningJ A Stead


Two crystal forms of disopyramide have been characterized using X-ray diffraction, differential scanning calorimetry and infrared spectroscopy. The kinetics of the solid state transformation of Form I to Form II has been analysed using the Prout-Tompkins theory. An activation energy of 144 kJ mol-1 is calculated for the system. Dissolution and plasma concentrations show no significant differences in bioavailability between the two polymorphs.


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Related Concepts

Metabolic Biotransformation
Disopyramide, L-Tartrate, (S)-isomer
Hydrogen-Ion Concentration
X-Ray Diffraction
Physicochemical Phenomena

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