Polymorphism of HLA class I genes in the Brazilian population from the Northeastern State of Pernambuco corroborates anthropological evidence of its origin

Tissue Antigens
P NigamR S Silva

Abstract

The allelic distribution of human leukocyte antigen (HLA) class I genes (HLA-A, HLA-B, and HLA-Cw) of the population from the State of Pernambuco in Northeastern Brazil was studied in a sample of 101 healthy unrelated individuals. Low to medium resolution HLA class I typing was performed using polymerase chain reaction-amplified DNA hybridized to sequence specific primers (PCR-SSPs). Twenty allele groups were detected for HLA-A, 28 for HLA-B, and 14 for HLA-Cw. The most frequent alleles were HLA-A*02(0.2871), HLA-B*15(0.1238), and HLA-Cw*04(0.2277), and the most frequent genotypes were A*02/A*02(0.0990), B*15/B*15(0.0594), and Cw*04/Cw*04 and Cw*07/Cw*07, both with a frequency of 0.0792. The observed heterozygosity for the studied loci was 79.21% for HLA-A, 87.13% for HLA-B, and 77.23% for HLA-Cw. The most frequent haplotype was A*02-Cw*04-B*35(0.0485), which is also present in Western European, Amerindian, and Brazilian Mulatto populations, but absent in African populations. Taken together, these data corroborate the historic anthropological evidences of the origin of the Northeastern Brazilian population from Pernambuco.

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Citations

Oct 11, 2012·Revista brasileira de hematologia e hemoterapia·Marlene Silva BardiEdson Lopes Lavado
Dec 18, 2007·Human Immunology·Annia FerrerMarta Dueñas
Jul 16, 2008·Journal of Clinical Laboratory Analysis·Sandra Marcia MuxelMaria Angelica Ehara Watanabe
Apr 9, 2015·Journal of Clinical Laboratory Analysis·Patrícia Keiko SaitoSueli Donizete Borelli
Apr 25, 2015·Revista da Associação Médica Brasileira·Marina Barguil MacêdoSemiramis Jamil Hadad do Monte
Jun 4, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E C CastelliJ L V de Camargo
Oct 10, 2019·HLA : Immune Response Genetics·Juliano A BoquettNelson J R Fagundes
Feb 28, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Fabiane Vieira Berg ShehadehSandra Mara Alessi Aristides
May 23, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sylvia Lopes Maia TeixeiraMariza Gonçalves Morgado

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