PMID: 6160591Oct 1, 1980Paper

Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system

Proceedings of the National Academy of Sciences of the United States of America
M L Markert, P Cresswell

Abstract

The B-cell alloantigens of an HLA-DR3-homozygous, MB2-homozygous, MT2-positive lymphoblastoid cell line were studied by two-dimensional gel electrophoresis. Analysis of gel patterns suggested assignment of the HLA-DR3 determinant to the larger (35,000-dalton) subunit (alpha) of the B-cell alloantigen. MB2 was found to be either a determinant on the small (27,000 dalton) subunit (beta) or a crossreactive determinant(s) on the HLA-DR3 alpha subunit and an additional alpha subunit. MT2 was found to be a determinant on Ia antigen-like molecules distinct from those carrying the MB and HLA-DR determinants. The results are consistent with the existence in the major histocompatibility complex of at least three loci encoding B-cell alloantigens.

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Citations

Aug 1, 1981·Human Immunology·J M PesandoS F Schlossman
Jun 1, 1982·Human Immunology·Y NakaiS Matsumoto
Feb 25, 1982·The New England Journal of Medicine·D J VolkmanA S Fauci
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D A ShackelfordJ L Strominger
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L M SmithH M McConnell
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C AuffrayJ L Strominger
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K WimanL Rask
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·O J Finn, R Levy
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A ZeeviR J Duquesnoy
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J MoriuchiJ Silver
Nov 1, 1982·The Journal of Experimental Medicine·C K HurleyJ D Capra
Jan 1, 1983·The Journal of Experimental Medicine·N TanigakiG B Ferrara
Aug 1, 1984·The Journal of Experimental Medicine·C K HurleyJ D Capra
Jan 1, 1982·Immunogenetics·V van HeyningenC M Steel
May 1, 1982·Clinical Immunology and Immunopathology·R J DuquesnoyK Halim
Jun 1, 1983·Journal of Immunogenetics·S L TonkonogyD B Amos

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