PMID: 15247628Jul 13, 2004Paper

Polymorphism of human mu class glutathione transferases

Pharmacogenetics
Natasha TetlowPhilip G Board

Abstract

A combined database mining approach was used to detect polymorphisms in the mu class glutathione-S-transferase (GST) genes. Although a large number of potential polymorphisms were detected in the five genes that comprise the Mu class GSTs using sequence alignment programs and by searching single nucleotide polymorphism databases, the majority were not validated or detected in three major ethnic populations (African, Southern Chinese and Australian European). Two new polymorphisms were detected and characterized in the GSTM3 gene. A rare pG147W substitution was detected only in the Southern Chinese subjects. A more common pV224I substitution was found in each of the ethnic groups studied, and significant differences in allele frequencies were observed between each group. These two polymorphisms can combine to form four distinct haplotypes (GSTM3A [p.G147;V224], GSTM3C [p.G147;I224], GSTM3D [p.W147;V224], GSTM3E [p.W147;I224]). The four isoforms were expressed in Escherichia coli and characterized enzymatically with several substrates including 1-chloro-2,4-dinitrobenzene (CDNB), cumene hydroperoxide and t-nonenal. GSTM3-3 containing the variant p.W147 residue tended to show diminished specific activity and catalytic efficiency w...Continue Reading

References

Mar 1, 1991·The Biochemical Journal·D J MeyerB Ketterer
Oct 15, 1991·Biochemical and Biophysical Research Communications·J L DeJongC P Tu
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N HariharanR P Perry
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W R VorachekG S Rule
Sep 15, 1989·The Biochemical Journal·P M BrophyJ Barrett
Dec 8, 1989·Biochimica Et Biophysica Acta·R C StrangeG J Beckett
Jan 1, 1989·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·H PeterE Hallier
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J SeidegårdW R Pearson
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B MannervikH Jörnvall
Jan 1, 1984·Human Genetics·V LaisneyJ Frezal
Jan 1, 1981·Methods in Enzymology·W H Habig, W B Jakoby
Oct 1, 1993·Science·F Collins, D Galas
Sep 1, 1996·Genome Research·L D HillierM Marra
Mar 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S EgyháziU Ringborg
Feb 12, 1998·Science·E Marshall
Aug 1, 1998·Genome Research·K M Weiss
Jul 9, 1999·Gene·A J Brookes

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Citations

Feb 26, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Gary GinsbergBabasaheb Sonawane
Jun 24, 2008·Journal of Toxicology and Environmental Health. Part a·Klaus GolkaSilvia Selinski
Aug 19, 2007·Pharmacogenetics and Genomics·Guilherme Suarez-KurtzSergio D J Pena
Apr 2, 2011·PloS One·Melanie J MorrisMarco G Casarotto
Apr 12, 2006·Biological Chemistry·Uwe ZimmermannReinhard Walther
Apr 22, 2008·Neurobiology of Aging·Olivier C MaesEugenia Wang
Jun 15, 2007·Biochimica Et Biophysica Acta·Neil R KitteringhamChris E Goldring
Jun 15, 2007·International Journal of Cancer. Journal International Du Cancer·Steffen LoftOle Raaschou-Nielsen
Feb 1, 2005·Archives of Biochemistry and Biophysics·Diane E Chico, Irving Listowsky
Dec 4, 2012·Biochimica Et Biophysica Acta·Philip G Board, Deepthi Menon
Jun 16, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D TeixeiraG Suarez-Kurtz
Jul 30, 2019·Frontiers in Endocrinology·Domenico MilardiAlfredo Pontecorvi
Oct 30, 2020·Cancer Management and Research·Shunda WangYupei Zhao
Dec 21, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ShiotaM Eto

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