Polymorphism of interleukin-1β and interleukin-1 receptor antagonist genes in children with autism spectrum disorders.

Progress in Neuro-psychopharmacology & Biological Psychiatry
Khaled SaadThamer A M Alruwaili

Abstract

In this study, we first investigated interleukin-1 beta (IL-1β) and IL-1 receptor antagonist (IL-1RA) levels in a cohort of Egyptian children with autism spectrum disorder (ASD) and in healthy controls. Second, we examined the single-nucleotide polymorphisms (SNPs) at positions -31 and - 511 of the IL-1β gene promoter and IL1RA and assessed the association between IL1B and IL1RA polymorphisms with ASD. We examined IL1β promoter polymorphism at -511 (IL-1β-511) and - 31 (IL-1β-31) and IL1RA gene polymorphism in 80 children with ASD and 60 healthy children. The children with ASD had significantly higher levels of IL-1β and IL-1RA than the controls. The children with ASD also had significantly higher frequencies of homozygous (CC) and heterozygous (TC) genotype variants of IL-1β-511, and IL-1RA than the controls. Moreover, the frequency of the IL-1β-511 allele (C) was higher in the ASD group than in the controls (p = .001). The homozygous and heterozygous variants of IL-1RA allele II were also significantly higher in the ASD group than in the control group. There was no significant association between the IL-1β-31 genotype and autism classes. However, there were significant differences in the distribution of the IL-1RA heterogeneo...Continue Reading

Citations

Jan 13, 2021·Immunological Investigations·Kubra Cigdem Pekkoc UyanikMehmet Seven
Feb 4, 2021·Child Psychiatry and Human Development·Khaled SaadKhaled Hashim Mahmoud

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