PMID: 3553940Mar 1, 1987Paper

Polymorphism of proteins in malaria parasites following mefloquine treatment

Molecular and Biochemical Parasitology
C PinswasdiK Pavanand

Abstract

Proteins in malaria parasites (Plasmodium falciparum) isolated from a patient in Thailand before treatment, and after recrudescence of infection subsequent to mefloquine treatment, were compared by two dimensional polyacrylamide gel electrophoresis (2D-PAGE) analysis. Nine 'pre-treatment' and six 'recrudescent' clones were studied. Variants of the enzyme glucose phosphate isomerase were also noted and mefloquine susceptibility of each clone was measured by in vitro tests. The 'pre-treatment' isolate was found to contain at least four genetically distinct clones, all sensitive to mefloquine, while the 'recrudescent' isolate contained at least two other types of clone, both showing increased tolerance to mefloquine. These two more tolerant types of clone differed from all the sensitive ones studied in regard to several different protein variants as shown by 2D-PAGE analysis. It is concluded that at least two (and probably more) genetically distinct clones of parasites with increased tolerance to mefloquine were present in the parasite population before mefloquine treatment was given, and were selected under mefloquine pressure.

References

Dec 1, 1979·Antimicrobial Agents and Chemotherapy·R E DesjardinsJ D Chulay
Aug 20, 1976·Science·W Trager, J B Jensen
Aug 1, 1985·Molecular and Biochemical Parasitology·B FentonD Walliker
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·S ThaithongM Chutmongkonkul
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·S ThaithongD Walliker
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·A SandersonJ F Molez

❮ Previous
Next ❯

Citations

Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·S ThaithongM Chutmongkonkul
Jul 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·E C ReisingerM Dietrich
May 1, 1987·Molecular and Biochemical Parasitology·B Fenton
Jul 1, 1995·Parasitology Today·F P Mockenhaupt
Oct 22, 2013·Journal of Proteomics·José M BautistaAntonio Puyet
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·S ThaithongG H Beale
Feb 1, 2006·Expert Review of Proteomics·Paul F G Sims, John E Hyde

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Transactions of the Royal Society of Tropical Medicine and Hygiene
M M Lemnge, A W Inambao
Parasitology Today
D C Gowda, I Davidson
Journal of Proteome Research
Marie L ThézénasCliment Casals-Pascual
© 2021 Meta ULC. All rights reserved