PMID: 9189012Jan 1, 1997Paper

Polymorphism of the human immunoglobulin heavy chain locus in rheumatoid arthritis

Autoimmunity
F FakhfakhM Zouali

Abstract

The genetic origin of Rheumatoid Arthritis (RA) is largely unknown. The purpose of this investigation was to assess the potential genetically determined involvement of the immunoglobulin (Ig) heavy chain variable region (VH) locus in the pathogenesis of RA. We tested the hypothesis of whether there is a genetic linkage between a structural abnormality of the VH gene complex and autoantibody hyperproduction in RA. We used restriction endonuclease generated polymorphism with human VH gene-family-specific probes to examine genomic DNA from a RA family and from unrelated RA patients from both the Tunisian and the European populations. The use of DNA samples from these ethnic origins permitted a further evaluation of the polymorphism of the human VH locus. While we found that the polymorphism of the VH locus was lower in the Tunisian population, we could not detect a restriction site polymorphism pattern restricted to RA. Together, our results do not support the involvement of major abnormalities of the Ig VH locus as a primary source in the development of RA.

References

Oct 1, 1992·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·P ChastagnerM Zouali
Dec 1, 1991·Revue française de transfusion et d'hémobiologie : bulletin de la Société nationale de transfusion sanguine·F FakhfakhH Ayadi
Aug 1, 1989·Journal of Autoimmunity·F SilvestrisR C Williams
Sep 1, 1989·European Journal of Immunology·M ZoualiB D Stollar
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P P ChenD A Carson
Jun 20, 1987·Journal of Molecular Biology·K H LeeT Honjo
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A ShenF Blattner
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Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Jan 1, 1995·Arthritis and Rheumatism·M McDermottB Mulcahy
Jun 1, 1994·Nature Genetics·M Zouali
Jun 14, 1963·Science·H G KunkelR C Williams

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Citations

Jul 9, 2004·Journal of Genetics·Abdellatif MaalejHammadi Ayadi

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