Polymorphism of the mast cell chymase gene (CMA1) promoter region: lack of association with asthma but association with serum total immunoglobulin E levels in adult atopic dermatitis

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
T IwanagaJ W Holloway

Abstract

Mast cell chymase has the potential to be an important mediator of inflammation and remodelling in the asthmatic lung. Previous studies have examined association between promoter polymorphism of the chymase gene (CMA1) and allergic phenotypes but the significance of this polymorphism is unclear. We have examined association of a CMA1 variant in relation to asthma in a large UK Caucasian family cohort. A polymorphism of the CMA1 gene promoter (-1903G/A) was genotyped in 341 asthmatic families and in 184 non-asthmatic adults recruited from the UK PCR-RFLP based genotyping. Association with asthma diagnosis, atopy, specific and total IgE, and atopy and asthma severity was examined. Case-control studies did not reveal a significant difference in allele frequency between asthmatics and controls. A significant association was found between CMA1 genotypes and total IgE levels in subjects with self-reported eczema that remained significant after correction for multiple testing (median total serum IgE GG 297 kU/L, GA 144 kU/L, AA 48.4 kU/L, Pc=0.0032). These data suggest that CMA1 promoter polymorphism does not contribute to asthma susceptibility or severity but may be involved in regulating IgE levels in patients with eczema.

References

May 28, 1994·Annals of the New York Academy of Sciences·J M Tunon de LaraA F Walls
Aug 1, 1996·The American Journal of Cardiology·A PfeuferF C Luft
Sep 13, 1996·Science·N Risch, K Merikangas
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·B J LongleyN M Schechter
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·P BergerJ M Tunon-de-Lara
Aug 26, 1998·European Journal of Pharmacology·S He, A F Walls
May 21, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K TanakaJ Furuyama
Aug 24, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J W HollowayS T Holgate
Nov 7, 1999·The Journal of Allergy and Clinical Immunology·S ForrestR Williamson
Mar 27, 2001·Immunology and Cell Biology·P H Hart
Sep 12, 2001·Allergy·S G JohanssonUNKNOWN EAACI (the European Academy of Allergology and Cinical Immunology) nomenclature task force
Mar 15, 2002·Chest·William Osmond Charles Cookson
May 31, 2002·The New England Journal of Medicine·Christopher E BrightlingIan D Pavord
Jul 12, 2002·Nature·Paul Van EerdeweghTim P Keith
Dec 25, 2002·Japanese Journal of Pharmacology·Teruaki ImadaTakao Kondo

❮ Previous
Next ❯

Citations

May 20, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sabine Hoffjan, Jörg T Epplen
Dec 29, 2007·Clinical Reviews in Allergy & Immunology·Yin-Hsiu ChienBor-Luen Chiang
Jan 23, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Chikako KiyoharaYoshihiro Miyake
Aug 26, 2010·Human Immunology·Martin HersbergerNicole Probst-Hensch
Jun 6, 2009·The Journal of Investigative Dermatology·Michael J CorkSimon J Ward
Nov 1, 2006·Allergy·P K Smith, J I Harper
Jan 1, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M AbdelmotelbJ W Holloway
Jul 29, 2011·Journal of Zhejiang University. Science. B·Chun-Na JinMei-Xiang Xiang
Mar 18, 2010·Blood·Gunnar PejlerSara Wernersson
Aug 9, 2016·The Journal of Allergy and Clinical Immunology·Monica G LawrenceThomas A E Platts-Mills
Aug 3, 2019·The European Respiratory Journal·Gunnar Pejler
Oct 20, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ali ArabkhazaeliSusanne J H Vijverberg
Nov 24, 2019·The Medical Clinics of North America·Jonathan I Silverberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.