Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Yi-Shin HuangShou-Dong Lee

Abstract

Antituberculosis drug-induced hepatitis is one of the most prevalent drug-induced liver injuries. Isoniazid is the major drug incriminated in this hepatotoxicity. Isoniazid is mainly metabolized to hepatotoxic intermediates by N-acetyltransferase (NAT). However, the association of polymorphic NAT acetylator status and antituberculosis drug-induced hepatitis is debatable. To determine whether acetylator status is a risk factor for antituberculosis drug-induced hepatitis, we genotyped NAT2 in 224 incident tuberculosis patients who received antituberculosis treatment. Antituberculosis drug-induced hepatitis was diagnosed based on a positive isoniazid rechallenge test and exclusion of viral hepatitis. Acetylator status was determined by genotyping NAT2 in patients using a polymerase chain reaction with restriction fragment length polymorphism. Univariate analysis and logistic regression analysis were used to evaluate the risk factors of isoniazid-induced hepatitis. Thirty-three patients (14.7%) were diagnosed with antituberculosis drug-induced hepatitis. Slow acetylators had a higher risk of hepatotoxicity than rapid acetylators (26.4% vs. 11.1%, P =.013). Among patients with hepatotoxicity, slow acetylators had significantly highe...Continue Reading

References

Nov 4, 1978·British Medical Journal·H Olsen, J Mørland
Feb 1, 1976·Annals of Internal Medicine·J R MitchellS D Nelson
Nov 1, 1977·Clinical Pharmacology and Therapeutics·J A TimbrellT A Baillie
Apr 1, 1976·Journal of Pharmacokinetics and Biopharmaceutics·G A Ellard, P T Gammon
Jul 1, 1975·Clinical Pharmacology and Therapeutics·J R MitchellH R Keiser
Feb 1, 1990·Gastroenterology·J C WuK J Lo
Mar 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T YamamotoC Hirayama
Dec 1, 1982·Journal of Toxicology and Environmental Health·M D Scales, J A Timbrell
Sep 1, 1981·Journal of Clinical Gastroenterology·D S DickinsonM M Hodgkin
Aug 1, 1995·The European Respiratory Journal·N P ThompsonN McIntyre
Oct 26, 1995·The New England Journal of Medicine·W M Lee
Feb 1, 1997·Pediatric Clinics of North America·J S Leeder, G L Kearns
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W M WongC L Lai
Apr 3, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D M BissellJ H Hoofnagle
Sep 1, 1961·The Journal of Pediatrics·W E NELSON

❮ Previous
Next ❯

Citations

Aug 19, 2004·European Journal of Clinical Pharmacology·Valery V BakayevAli A Velayati
Jun 14, 2006·European Journal of Clinical Pharmacology·Nicolas VuilleumierDenis Hochstrasser
Oct 14, 2010·European Journal of Clinical Pharmacology·Sang-Heon KimYoung Koo Jee
Dec 20, 2012·Current Gastroenterology Reports·Jonathan G StineJames H Lewis
Aug 12, 2009·Hepatology International·Hoda A MakhloufHebat Alla G Rashed
Jul 13, 2013·The Journal of Infection·April C PettitUNKNOWN Tuberculosis Epidemiologic Studies Consortium
Oct 22, 2003·Journal of Hepatology·Dimitrios Petrou Bogdanos, Ian G McFarlane
Mar 3, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Hsin-Yun SunKwen-Tay Luh
Sep 3, 2010·Nature Reviews. Gastroenterology & Hepatology·Bahaa E SenousyPeter V Draganov
Nov 29, 2007·European Journal of Human Genetics : EJHG·Hélène MagalonEvelyne Heyer
Jun 6, 2007·The Pharmacogenomics Journal·D Tomalik-ScharteJ Kirchheiner
Mar 3, 2010·The Pharmacogenomics Journal·S YamadaA Brooks-Wilson
Aug 2, 2003·The New England Journal of Medicine·William M Lee
Feb 17, 2006·The New England Journal of Medicine·Victor J Navarro, John R Senior
Nov 17, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephen H Gillespie
Jan 15, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·David H AdamsHartmut Jaeschke
Mar 11, 2005·Journal of Clinical Gastroenterology·Willis C Maddrey
Dec 20, 2003·Annals of Surgery·Peter L AbtJames F Markmann
Feb 15, 2013·Pharmacogenetics and Genomics·Hsin-Tien HoOliver Yoa-Pu Hu
Apr 18, 2012·Clinical and Experimental Pharmacology & Physiology·Hui-Ru AnYan Liang
Oct 26, 2005·Journal of Gastroenterology and Hepatology·Subhash AgalDeepak Amarapurkar
Nov 13, 2007·Journal of Gastroenterology and Hepatology·Alma TostmannRichard Dekhuijzen
Jan 26, 2011·Journal of Gastroenterology and Hepatology·Purabi Deka BosePremashis Kar
Oct 2, 2012·Journal of Gastroenterology and Hepatology·Harshad DevarbhaviGirisha Balaraju
Oct 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Wing Wai Yew, Chi Chiu Leung
Apr 28, 2005·Antimicrobial Agents and Chemotherapy·Martina Kinzig-SchippersUwe Fuhr
Aug 2, 2006·Annual Review of Pharmacology and Toxicology·Jack Uetrecht
Oct 6, 2006·American Journal of Respiratory and Critical Care Medicine·Jussi J SaukkonenUNKNOWN ATS (American Thoracic Society) Hepatotoxicity of Antituberculosis Therapy Subcommittee
Apr 5, 2008·American Journal of Respiratory and Critical Care Medicine·Kwok C ChangCheuk M Tam
Feb 13, 2007·Environmental Health : a Global Access Science Source·Eckart SchnakenbergWerner Schloot
Jan 31, 2013·Genome Medicine·Ann K Daly
Nov 1, 2013·Drug Metabolism and Pharmacokinetics·Ke LiuXiaochao Ma
Dec 12, 2012·Pharmacogenomics and Personalized Medicine·Geetha Ramachandran, Soumya Swaminathan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.