PMID: 40340Jan 1, 1979

Polymorphism of the second component of human complement (C2). Observation of the rare phenotype (C2 2 (= C2 B) and data on the localization of the C2 locus in the HLA region

Vox Sanguinis
G Dewald, C Rittner

Abstract

The polymorphism of the second component of human complement was studied by means of isoelectric focusing in polyacrylamide gels with subsequent complement-dependent lysis of sensitized sheep erythrocytes in an agarose overlay containing C2-deficient or normal human serum. In a material of 289 unrelated individuals the following gene frequencies were observed: C21=0.965 and C22=0.035. The rare phenotype C2 2 (=C2 B) could be seen once in a child of a C2 1--2 heterozygous mother. The investigation of the C2/HLA relationship revealed a very close linkage: Among 62 informative meiotic divisions one recombination between HLA-B and C2 was found (i.e. 1.61%); in addition, C2(2) was significantly associated with HLA-B15 and -Cw3. In a family with an HLA-B/D(DR) crossover C2 segregated together with HLA-D(DR). This supports the assumption of a C2 structural locus outside HLA-B, probably near HLA-D(DR).

References

Jan 1, 1981·Human Genetics·C Rittner, J Bertrams
Jan 1, 1981·Human Genetics·K TokunagaK Omoto
Jan 1, 1985·Human Genetics·G DoxiadisH Grosse-Wilde
Jan 1, 1985·Human Genetics·J R Regueiro, A Arnaiz-Villena
Jan 1, 1983·Archives of Dermatological Research·G DewaldH W Kreysel
Nov 1, 1981·Tissue Antigens·P MiniterG J O'Neill
Mar 1, 1985·Diabetes Research and Clinical Practice·R L KirkM Viswanathan
Mar 1, 1985·Jinrui idengaku zasshi. The Japanese journal of human genetics·K S ParkK Omoto
Dec 1, 1980·Jinrui idengaku zasshi. The Japanese journal of human genetics·K TokunagaT Juji
Feb 1, 1984·Tissue Antigens·C RittnerA Carbonara
May 1, 1983·Tissue Antigens·C RittnerI Stroehmann

Citations

Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T MeoR Ceppellini
Jan 1, 1978·Medicine·V Agnello
Apr 1, 1978·The Biochemical Journal·M A Kerr, R R Porter
Jan 1, 1976·Transplantation Reviews·C JersildN K Day
Jan 1, 1976·Transplantation Reviews·M J Hobart, P J Lachmann
Jun 1, 1975·The Journal of Experimental Medicine·N K DayC Jersild
Jun 1, 1966·The Journal of Clinical Investigation·M R KlempererK F Austen

Related Concepts

Pathologic Cytolysis
Establishment and Maintenance of Localization
Polyacrylamide Gels
Complement Component 2 Deficiency
Recombination, Genetic
HLA-B gene
HLA Antigens
Genome Mapping
Haploid Cell
Complement 2

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