Polymorphism of the serotonin transporter gene (5-HTTLPR) in major depressive disorder patients in Malaysia

Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists
Suriati Mohamed SainiAbdul Hamid Abdul Rahman

Abstract

The serotonin transporter promoter (5-HTTLPR) is a potential susceptibility locus in the pathogenesis of major depressive disorder. However, data from Malaysia is lacking. The present study aimed to determine the association between the homozygous short variant of the serotonin transporter promoter gene (5-HTTLPR) with major depressive disorder. This is a candidate gene case-control association study. The sample consists of 55 major depressive disorder probands and 66 controls. They were Malaysian descents and were unrelated. The Axis I diagnosis was determined using Mini International Neuropsychiatric Interview (M.I.N.I.). The control group comprised healthy volunteers without personal psychiatric history and family history of mood disorders. Participants' blood was sent to the Institute Medical Research for genotyping. The present study failed to detect an association between 5-HTTLPR ss genotype with major depressive disorder (χ(2)  = 3.67, d.f. = 1, P = 0.055, odds ratio 0.25, 95% confidence interval = 0.07-1.94). Sub-analysis revealed that the frequency of l allele in healthy controls was higher (78.0%) than that of Caucasian and East Asian population. However, in view of the small sample size this study may be prone to ty...Continue Reading

References

Mar 24, 1997·Neuroreport·D BallR Plomin
Dec 5, 1998·American Journal of Human Genetics·D ComasJ Bertranpetit
May 10, 2000·American Journal of Human Genetics·S A BacanuK Roeder
Jul 25, 2000·Journal of the National Cancer Institute·S WacholderN Caporaso
Dec 26, 2001·Brain Research Bulletin·D L MurphyG Uhl
Jul 20, 2002·Science·Ahmad R HaririDaniel R Weinberger
Nov 13, 2003·Journal of Affective Disorders·Thomas E JoinerJessica S Brown
Apr 14, 2005·European Journal of Human Genetics : EJHG·Georgia SalantiJohn P A Ioannidis
Sep 20, 2005·European Journal of Epidemiology·John P A Ioannidis
Jan 18, 2006·American Journal of Epidemiology·Thomas A TrikalinosJohn P A Ioannidis
Sep 20, 2006·Molecular Biology and Evolution·Catherine HillMartin Richards
Apr 17, 2010·Nature Reviews. Genetics·Noah A RosenbergMichael Boehnke
Apr 13, 2011·PloS One·Wan Isa HatinUNKNOWN HUGO Pan-Asian SNP Consortium

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.