Polymorphism of TPH2 Gene rs120074175 Is Not Associated with Risk Factors of Schizophrenia

Journal of Pharmacy & Bioallied Sciences
James P LaksonoMelisa I Barliana

Abstract

Polymorphism on tryptophan hydroxylase 2 (TPH2) gene rs120074175 can cause the synthesis of neurotransmitter serotonin in the brain to reduce up to 80%. Reduced serotonin in the brain can cause dopamine release to occur continuously. Excess dopamine in the brain may cause positive symptom of schizophrenia. The aim of this study was to investigate the genotype distribution of TPH2 rs120074175 gene on patients with schizophrenia at Prof. Dr. Soerojo Magelang Psychiatric Hospital, Indonesia, and the relationship between the genetic polymorphism of the TPH2 rs120074175 gene against risk factors of schizophrenia. This was a cross-sectional study. The method used was amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Whole blood from healthy subjects and patients with schizophrenia, Wizard genomic deoxyribonucleic acid (DNA) purification kit (Promega, Fitchburg, Wisconsin), PCR master mix (Promega), ARMS-PCR primers, ddH2O, agarose (Thermo Scientific, Seoul, South Korea), Tris, Acetic Acid, EDTA (TAE) 1X, ethidium bromide, loading dye 6×, and DNA ladder (Thermo Scientific) were the materials used. Hardy-Weinberg equilibrium and chi-square (χ2) tests were used. The results showed that both groups (healthy s...Continue Reading

References

Jul 13, 2004·Science·Xiaodong ZhangMarc G Caron
Feb 23, 2008·Schizophrenia Research·Rajiv TandonHenry A Nasrallah
Jun 14, 2012·PloS One·Jin GaoEvangelos Evangelou
Jan 10, 2018·Journal of Cellular and Molecular Medicine·Paulina WignerTomasz Sliwinski

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