Polymorphism of two very similar MHC class Ib loci in rainbow trout (Oncorhynchus mykiss)

Immunogenetics
Johannes Martinus DijkstraMitsuru Ototake

Abstract

As part of an ongoing elucidation of rainbow trout major histocompatibility complex (MHC) class I, the polymorphism of two MHC class Ib loci was analyzed. These loci, Onmy-UCA and Onmy-UDA, are situated head-to-tail and share more than 89% nucleotide identity in their open reading frames. They share 80% identity with some trout Ia alleles. The deduced amino acid sequences suggest that the UCA and UDA molecules are transported to endosomal compartments and may bind peptides in their binding groove. Our survey revealed seven UCA and eight UDA alleles. Similarity indices overlap when comparing within and between UCA and UDA alleles and some cross-locus motif variation is observed. In most trout both UCA and UDA transcripts were found. However, there probably is functional redundancy, because some trout lacked transcription of one of the two loci. Furthermore, for some UCA and UDA alleles, splicing deficiencies, early stop codons, and upstream start codons were found, which may interfere with efficient protein expression. The present study is the first extensive report on MHC class Ib polymorphism assigned to locus in ectotherm species.

References

May 20, 1991·Journal of Molecular Biology·M A SaperD C Wiley
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K HashimotoY Kurosawa
Jan 1, 1989·Annual Review of Immunology·A Townsend, H Bodmer
Dec 1, 1995·The Journal of Experimental Medicine·D BarouchH G Rammensee
Jan 1, 1995·Annual Review of Immunology·D R Madden
Aug 25, 1995·The Journal of Biological Chemistry·L PondP A Peterson
Jan 1, 1995·Immunogenetics·H G RammenseeS Stevanoviíc
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·B P ShumP Parham
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·N MizukiH Inoko
Nov 1, 1996·Developmental and Comparative Immunology·J D HansenL Du Pasquier
Jan 1, 1997·Annual Review of Immunology·K F LindahlM Yoshino
Jan 23, 1999·Immunological Reviews·K M Miller, R E Withler
Feb 27, 1999·Current Opinion in Immunology·V M BraudA J McMichael
Jun 25, 1999·Immunogenetics·B P ShumP Parham
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J D Hansen, P Strassburger
Jun 22, 2000·Journal of Molecular Biology·L A KelleyM J Sternberg
Nov 14, 2000·Molecular and Cellular Biology·D R Morris, A P Geballe
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B P ShumP Parham
Nov 7, 2001·Developmental and Comparative Immunology·T NakanishiM Ototake
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazuhiko AoyagiTeruyuki Nakanishi
Oct 22, 2002·Immunogenetics·Attila KumánovicsKirsten Fischer Lindahl
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katharine E MagorPeter Parham
Apr 15, 2005·Molecular Immunology·L J MooreI Hordvik

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Citations

Jan 23, 2016·Biology·Unni Grimholt
Mar 13, 2012·Ecology and Evolution·Morten T LimborgJames E Seeb
Apr 19, 2015·BMC Evolutionary Biology·Unni GrimholtJohannes M Dijkstra
Apr 28, 2019·Cells·Takuya Yamaguchi, Johannes M Dijkstra
Apr 21, 2009·Bioorganicheskaia khimiia·O S BychenkoE D Sverdlov
Jul 3, 2016·Immunogenetics·Eva-Stina EdholmJacques Robert
Jan 31, 2021·BMC Ecology and Evolution·U Grimholt, M Lukacs

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