Polymorphism of vascular endothelial growth factor -2578C/A with cancer risk: evidence from 11263 subjects.

Medical Oncology
C CaoZai-Chun Deng

Abstract

Published data on the association between vascular endothelial growth factor (VEGF) -2578C/A polymorphism and cancer risk is inconclusive. To derive a more precise estimation of association between VEGF -2578C/A polymorphism and the risk of cancer, we performed a meta-analysis of 5415 cancer cases and 5848 controls from 16 published case-control studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Our meta-analysis indicated that VEGF -2578C/A polymorphism was associated with the risk of colorectal cancer under homozygote comparison (OR=0.70, 95% CI=0.53-0.92), dominant model (OR=0.72, 95% CI=0.57-0.92), and recessive model (OR=0.82, 95% CI=0.67-1.01), although no evidence of association between VEGF -2578C/A polymorphism and cancer risk was observed as we compared in the pooled analyses (homozygote comparison: OR=0.97, 95% CI=0.81-1.16). More studies are needed to detect VEGF -2578C/A polymorphism and its association with cancer in different ethnic populations incorporated with environmental exposures in the susceptibility of different kinds of cancer.

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Citations

Jul 3, 2013·Japanese Journal of Clinical Oncology·Yan WangMing Chu
Dec 2, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alicia Beeghly-FadielWei Zheng
Oct 23, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zai-Chun DengMeng Ye
Aug 29, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ning SongCongmin Zhang
Dec 22, 2010·Journal of Cancer Research and Clinical Oncology·Liu LiuPei-Qian Zhu
Apr 13, 2017·Human Brain Mapping·Hikaru TakeuchiRyuta Kawashima
Dec 4, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Junwei TuJianghua Tian
Jan 8, 2014·Experimental and Therapeutic Medicine·Zai-Chun DengHong-Ying Ma

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