Polymorphism rs4919510:C>G in mature sequence of human microRNA-608 contributes to the risk of HER2-positive breast cancer but not other subtypes.

PloS One
A-Ji HuangZhi-Ming Shao

Abstract

A few polymorphisms are located in the mature microRNA sequences. Such polymorphisms could directly affect the binding of microRNA to hundreds of target mRNAs. It remains unknown whether rs4919510:C>G located in the mature miR-608 alters breast cancer susceptibility. The association of rs4919510:C>G with risk and pathologic features of breast cancer were investigated in two independent case-control studies, the first set including 1,138 sporadic breast cancer patients (including 927 invasive ductal carcinoma patients, 777 of them with known subtypes: 496 luminal-like, 133 HER2-positive, and 148 triple-negative) and 1,434 community-based controls, and the second set including 294 familial/early-onset breast cancer patients and 500 hospital-based cancer-free controls. Odds ratios (ORs) were estimated by logistic regression. Predicted targets of miR-608 and complementary sequences containing rs4919510:C>G were surveyed to reveal potential pathological mechanism. In the first set, although rs4919510:C>G was unrelated to breast cancer in general patients, variant genotypes (CG/GG) were specifically associated with increased risk of HER2-positive subtype (Adjusted OR = 1.97, 95% CI, 1.34-2.90 in the recessive model). Variant G-allele...Continue Reading

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Citations

Jul 16, 2014·Cell Stress & Chaperones·Tiffany M BridgesJeffrey D Hasday
Jan 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-Pin MaDe-Ke Jiang
Jun 10, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ping ZhangMinghua Wang
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shuangshuang WuMinjie Chu
Sep 10, 2014·Menopause : the Journal of the North American Menopause Society·HyungChul RahNam Keun Kim
Jan 13, 2018·PloS One·Hsiu-Pei TsaiShin-Cheh Chen
Oct 28, 2017·International Journal of Oncology·Norahayu Othman, Noor Hasima Nagoor
Oct 17, 2019·International Journal of Molecular Sciences·Milad BastamiZiba Nariman-Saleh-Fam
Jan 24, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fuman QiuJiachun Lu

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Methods Mentioned

BETA
genotyping

Software Mentioned

MicroCosm Targets
RNAfold
STATA
MicroCosm
SPSS
Quanto
TargetScan

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