Abstract
Glutathione S-transferases (GSTs) are involved in the metabolism of carcinogens and anticancer drugs. Functional polymorphisms exist in at least three genes that code for the GSTs, such as the GSTM1 and GSTT1 gene deletions or the A-G transition within the GSTP1 gene, which represents distinct GSTP1a and GSTP1b alleles. In the present case-control study, we aimed at estimation of the relationship between the GSTM1, GSTT1, and GSTP1 genotypes and the susceptibility to various types of childhood malignancies and the early relapses of diseases. Using the polymerase chain reaction on the DNA extracted from peripheral blood leukocytes, we identified the GSTM1, GSTT1, and GSTP1 genotypes in 234 children at the initial stage of a childhood malignancy as well as in 460 age-and sex-matched healthy subjects who served as controls. The follow-up period for the effects of the anticancer therapy ranged from 11 to 43 months. Compared to the controls, a significant increase in the frequency of the GSTP1b/GSTP1b genotype (odds ratio (OR) 5.7; 95% confidence limit (CL) from 2.4 to 13.8; Pearsons Chi-square P = 0.0001) was detected in the children with neoplasms. The GSTM1 and GSTT1 genotypes did not show any correlation with the risk of the de ...Continue Reading
References
Sep 1, 1991·Carcinogenesis·S ZhongN K Spurr
May 1, 1995·Carcinogenesis·H H NelsonX Xu
May 15, 1994·The Biochemical Journal·S PembleJ B Taylor
May 1, 1994·Carcinogenesis·H J LinS Hardy
Apr 1, 1997·Carcinogenesis·L W HarriesC R Wolf
Jul 1, 1997·Carcinogenesis·D RybergA Haugen
Jan 1, 1997·Archives of Toxicology·T BrüningH M Bolt
Apr 16, 1998·Journal of the National Cancer Institute·K J HelzlsouerD Bell
Jun 20, 1998·Journal of Molecular Biology·A S JohanssonB Mannervik
Jul 29, 1998·Chemico-biological Interactions·C J HendersonC R Wolf
Oct 17, 1998·Biochemical Pharmacology·C S MorrowA J Townsend
Mar 2, 1999·British Journal of Haematology·M L Den BoerA J Veerman
Jun 22, 2000·Molecular Pharmacology·L A RosarioK D Tew
Feb 24, 2001·Pharmacogenetics·G AndererM Stanulla
Feb 24, 2001·Experimental Lung Research·M S MillerM G O'Sullivan
Jul 24, 2001·Medical and Pediatric Oncology·Y Tsuchida, P Therasse
Sep 6, 2001·Mutation Research·M DusinskáA R Collins
Sep 6, 2001·Mutation Research·B SchoketI Vincze
Sep 6, 2001·Mutation Research·W K Lutz
Nov 1, 2001·Respiratory Research·A HemmingsenM A Spiteri
Dec 1, 2001·International Journal of Hygiene and Environmental Health·H Norppa
May 16, 2002·Blood·Martin YuilleRichard Houlston
Jul 26, 2002·British Journal of Haematology·Ian KerridgeAndrew Spencer
Aug 13, 2002·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Steven S Coughlin, Ingrid J Hall
Nov 20, 2002·Pharmacogenetics·Maja KrajinovicDaniel Sinnett
Jan 1, 1993·Cytotechnology·U ArmatoH Suzuki
Citations
Oct 17, 2008·Radiation Protection Dosimetry·Anand P Chokkalingam, Patricia A Buffler
Nov 12, 2005·Journal of Pediatric Hematology/oncology·Elzbieta ZielińskaKonrad Misiura
Sep 11, 2009·Pharmacogenetics and Genomics·Sigrid M KraggerudRagnhild A Lothe
Sep 15, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Susan Searles NielsenRoberta McKean-Cowdin
Dec 19, 2006·BMC Cancer·Zemin WangJia-Sheng Wang
Aug 16, 2005·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Y LiP W Brandt-Rauf
Feb 2, 2008·Current Problems in Pediatric and Adolescent Health Care·Lucy M Anderson
Jul 11, 2006·Mutation Research·Lucy M Anderson
Oct 5, 2019·Journal of Oncology·Edgar Ledesma-MartínezEdelmiro Santiago-Osorio