Polymorphism within the glutathione S-transferase P1 gene is associated with increased susceptibility to childhood malignant diseases

Pediatric Blood & Cancer
Elzbieta ZielińskaJerzy Bodalski

Abstract

Glutathione S-transferases (GSTs) are involved in the metabolism of carcinogens and anticancer drugs. Functional polymorphisms exist in at least three genes that code for the GSTs, such as the GSTM1 and GSTT1 gene deletions or the A-G transition within the GSTP1 gene, which represents distinct GSTP1a and GSTP1b alleles. In the present case-control study, we aimed at estimation of the relationship between the GSTM1, GSTT1, and GSTP1 genotypes and the susceptibility to various types of childhood malignancies and the early relapses of diseases. Using the polymerase chain reaction on the DNA extracted from peripheral blood leukocytes, we identified the GSTM1, GSTT1, and GSTP1 genotypes in 234 children at the initial stage of a childhood malignancy as well as in 460 age-and sex-matched healthy subjects who served as controls. The follow-up period for the effects of the anticancer therapy ranged from 11 to 43 months. Compared to the controls, a significant increase in the frequency of the GSTP1b/GSTP1b genotype (odds ratio (OR) 5.7; 95% confidence limit (CL) from 2.4 to 13.8; Pearsons Chi-square P = 0.0001) was detected in the children with neoplasms. The GSTM1 and GSTT1 genotypes did not show any correlation with the risk of the de ...Continue Reading

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Citations

Oct 17, 2008·Radiation Protection Dosimetry·Anand P Chokkalingam, Patricia A Buffler
Nov 12, 2005·Journal of Pediatric Hematology/oncology·Elzbieta ZielińskaKonrad Misiura
Sep 15, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Susan Searles NielsenRoberta McKean-Cowdin
Aug 16, 2005·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Y LiP W Brandt-Rauf
Feb 2, 2008·Current Problems in Pediatric and Adolescent Health Care·Lucy M Anderson
Oct 5, 2019·Journal of Oncology·Edgar Ledesma-MartínezEdelmiro Santiago-Osorio

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