Polymorphisms and the differential antiviral activity of the chicken Mx gene

Genome Research
Jae Hong KoTomomasa Watanabe

Abstract

The nucleotide sequence of chicken Mx cDNA was reported earlier using the White Leghorn breed in Germany, but it showed no enhanced resistance to viruses. In this study, the nucleotide sequences of chicken Mx cDNA were determined in many breeds. A total of 25 nucleotide substitutions, of which 14 were deduced to cause amino acid exchanges, were detected, suggesting that the chicken Mx gene is very polymorphic. Transfected cell clones expressing chicken Mx mRNA were established after the Mx cDNA was constructed with an expression vector and introduced into mouse 3T3 cells, and the Mx genes from some breeds were demonstrated to confer positive antiviral responses to influenza virus and vesicular stomatitis virus. On the basis of the comparison among the antiviral activities associated with many Mx variations, a specific amino acid substitution at position 631 (Ser to Asn) was considered to determine the antivirally positive or negative Mx gene. Thus, a single amino acid substitution influences the antiviral activity of Mx in domesticated chickens.

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Citations

Nov 23, 2006·Immunogenetics·H A E BabikerT Watanabe
Aug 30, 2008·Immunogenetics·Sofia BerlinHans Ellegren
Sep 8, 2005·Biochemical Genetics·Lin Hua JuTomomasa Watanabe
Dec 31, 2003·Developmental and Comparative Immunology·Stephen M AltmannCarol H Kim
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Jul 2, 2010·Animal Health Research Reviews·Hadi M YassineYehia M Saif
Mar 16, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Teppei NakamuraTakashi Agui
Apr 7, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Michael LeroyDaniel Desmecht
Nov 1, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Silke StertzGeorg Kochs
Feb 11, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kohji YamadaTomomasa Watanabe
Jun 3, 2011·Journal of Virology·Benjamin SchusserSonja Härtle
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Jul 12, 2008·Veterinary Immunology and Immunopathology·Luciana SarmentoMary Pantin-Jackwood
May 19, 2004·Animal Genetics·Y NakatsuT Watanabe

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