Polymorphisms at the beta2-adrenergic receptor gene influence Alzheimer's disease susceptibility

Brain Research
Jin-Tai YuYan-Ping Sun

Abstract

Increasing evidence indicates that the beta2-adrenergic receptor (beta2-AR) may play an important role in Alzheimer's disease (AD). We investigated the effect of two polymorphisms in the beta2-AR gene: Gly16Arg and Gln27Glu for the risk of sporadic Late Onset Alzheimer's Disease (LOAD) in 109 patients and 109 healthy controls matched for sex and age in a Han Chinese population. Results revealed that both the 16Gly allele and the 27Glu allele of the beta2-AR gene were associated with an increased risk of LOAD (P=0.009, OR=1.652 and P=0.002, OR=2.846, respectively), and they also showed a highly significant interaction with the Apolipoprotein E gene (APOE) epsilon4 allele (OR=4.200 and 9.441, respectively). Examination of the haplotypes identified the Gly16Glu27 haplotype to increase the risk of LOAD (P=0.004). Our results suggest that variations in the beta2-AR gene play an important role in the pathogenesis of sporadic LOAD, and interact with the epsilon4 allele to markedly increase the LOAD risk.

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Citations

Mar 9, 2012·Journal of Molecular Neuroscience : MN·Jun-hong DongJin-peng Sun
May 17, 2013·Molecular Neurobiology·Teng JiangLan Tan
Apr 17, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dayong WangYang K Xiang
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Jun 4, 2019·Frontiers in Pharmacology·Maria Grazia Morgese, Luigia Trabace
Jun 9, 2021·Seminars in Cell & Developmental Biology·Mara Mather

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