Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients

Journal of Neurovirology
Hayley GoulleeP Price

Abstract

HIV-associated sensory neuropathy (HIV-SN) is the most common neurological condition associated with HIV. HIV-SN has characteristics of an inflammatory pathology caused by the virus itself and/or by antiretroviral treatment (ART). Here, we assess the impact of single-nucleotide polymorphisms (SNPs) in a cluster of three genes that affect inflammation and neuronal repair: P2X7R, P2X4R and CAMKK2. HIV-SN status was assessed using the Brief Peripheral Neuropathy Screening tool, with SN defined by bilateral symptoms and signs. Forty-five SNPs in P2X7R, P2X4R and CAMKK2 were genotyped using TaqMan fluorescent probes, in DNA samples from 153 HIV(+) black Southern African patients exposed to stavudine. Haplotypes were derived using the fastPHASE algorithm, and SNP genotypes and haplotypes associated with HIV-SN were identified. Optimal logistic regression models included demographics (age and height), with SNPs (model p < 0.0001; R (2) = 0.19) or haplotypes (model p < 0.0001; R (2) = 0.18, n = 137 excluding patients carrying CAMKK2 haplotypes perfectly associated with SN). Overall, CAMKK2 exhibited the strongest associations with HIV-SN, with two SNPs and six haplotypes predicting SN status in black Southern Africans. This gene warran...Continue Reading

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Citations

Nov 3, 2020·Journal of Cell Communication and Signaling·Mohd Altaf NajarT S Keshava Prasad
Sep 15, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ahmad Yanuar SafriPatricia Price
Nov 24, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Thomas JulianPanagiotis Zis
Jan 14, 2021·Cellular & Molecular Immunology·Chintan Chhatbar, Marco Prinz
Apr 27, 2021·Frontiers in Immunology·Jean M KanellopoulosDavid M Ojcius
Dec 9, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jessica GaffPatricia Price

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