Abstract
Recurrent pregnancy loss (RPL) can be caused due to diverse factors with thrombophilia being one of them. The association of various thrombophilic risk factors with RPL is inconsistent in different studies and the frequency of these risk factors in Indian population is obscure. Five hundred and eighty patients with either recurrent early miscarriage or a history of at least one late miscarriage were screened for deficiency of protein C (PC), protein S (PS), antithrombin III (AT), APC resistance and prothrombin 20210G > A mutation. APC resistance positive patients were typed for the factor V Leiden, factor V Hong Kong/Cambridge mutations, and HR2 haplotype. PstI and rs2227589 AT mutations were detected by direct sequencing. APC resistance (13.4 %) was detected to be most common in Indian RPL patients followed by PS (10.6 %), PC (9.8 %) and AT deficiency (4.31 %.). FV Leiden was shown to be associated with APC resistance while HR2 haplotype was not associated with APC resistance (p values: 0.0001 and 0.327 respectively) and the increased risk of RPL. PstI and rs2227589 polymorphisms were similar in patients and controls and not associated with AT deficiency in RPL. Our study emphasizes the presence of other contributory factors t...Continue Reading
References
Jun 30, 1983·The New England Journal of Medicine·E V ProchownikS H Orkin
Jul 1, 1995·British Journal of Haematology·A M CummingC R Hay
Dec 1, 1994·The Journal of Clinical Investigation·B ZöllerB Dahlbäck
Feb 24, 1994·The New England Journal of Medicine·P J Svensson, B Dahlbäck
May 1, 1996·Thrombosis Research·T YamazakiH Saito
Jun 1, 1997·Journal of Vascular Surgery·M C DonaldsonD M Dorfman
Feb 22, 2003·Blood·Veronique PicardMartine Aiach
Mar 22, 2003·Lancet·Evelyne ReyIan Shrier
Dec 9, 2003·The Journal of Biological Chemistry·Marijn van der Neut KolfschotenRogier M Bertina
Apr 8, 2006·Thrombosis and Haemostasis·Walid ZammitiJean-Christophe Gris
May 25, 2006·Bioinformatics·Xavier SoléVíctor Moreno
Mar 18, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Arijit BiswasRenu Saxena
Mar 20, 2008·JAMA : the Journal of the American Medical Association·Irene D BezemerFrits R Rosendaal
Feb 21, 2009·Haematologica·Ana I AntónBeatriz Sánchez-Vega
Oct 26, 2011·Genetic Testing and Molecular Biomarkers·Svetlana MadjunkovaDijana Plaseska-Karanfilska
Jun 1, 2010·Journal of Community Genetics·Nadja Bogdanova, Arseni Markoff
May 12, 2012·Thrombosis·Henry CardonaAngela P Cadavid
Citations
Aug 1, 2015·Blood Cells, Molecules & Diseases·Amit SharmaRenu Saxena
Jan 25, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Zuying XuHuifen Xiang
Jul 2, 2019·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Jelena VelickovicOliver Stojkovic
May 31, 2020·Archives of Gynecology and Obstetrics·Bahareh HamediConsolato Sergi
Jul 1, 2020·Thrombosis Journal·Mohammad Masoud EslamiBahman Razi
Feb 13, 2021·Human Reproduction·Xiaoling LiuTingting Wang