Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan

BMC Genetics
Aisha N IskakovaErlan M Ramanculov

Abstract

Studies of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are crucial to the development of therapeutics in clinical medicine. Such data provide information that may improve our understanding of individual differences in sensitivity or resistance to certain drugs, thereby helping to avoid adverse drug reactions (ADRs) in patients and improve the quality of therapies. Here, we aimed to analyse single nucleotide polymorphisms (SNPs) involved in the ADME of multiple drugs in Kazakhs from Kazakhstan. A total of 158 SNPs involved in the ADME of various drugs were studied. We analysed 320 Kazakh DNA samples using OpenArray genotyping. Of the 158 SNPs, 75 were not found in heterozygous or homozygous variants. Comparative analysis among Kazakhs and world populations showed a fairly high percentage of population differentiation. These results provide further information for pharmacogenetic databases and may contribute to the development of personalized approaches and safer therapies for the Kazakh population. Moreover, these data provide insights into the different racial groups that may have contributed to the Kazakh population.

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Citations

Aug 20, 2016·Journal of the Neurological Sciences·Shiek S S J AhmedV Ramakrishnan
Jul 12, 2018·BioMed Research International·Recep Dursunİlknur Çınar
Aug 28, 2021·Balkan Journal of Medical Genetics : BJMG·Z Abrahams-OctoberJ Jebio Ongole

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

HapMap Genome Browser
Arlequin
Haploview
TaqMan Genotyper

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