Polymorphisms in hOGG1 and XRCC1 and risk of prostate cancer: effects modified by plasma antioxidants.

Urology
Jianjun ZhangFred F Kadlubar

Abstract

To investigate whether polymorphisms in genes involved in the repair of oxidative DNA damage, modulate, and/or interact with antioxidants to influence prostate cancer risk in a population-based case-control study in Central Arkansas. Accumulating evidence indicates that oxidative stress plays a role in prostate carcinogenesis. Cases (n = 193) included men aged 40-80 years, diagnosed with prostate cancer in 3 major hospitals in 1998-2003, and controls (n = 197) were matched to cases by age, race, and county of residence. After adjustment for confounders, subjects who were heterozygous or homozygous for the variant allele of the hOGG1 Ser326Cys polymorphism appeared to experience a lower risk of prostate cancer than those who were homozygous for the wild-type allele (odds ratio [OR] (95% confidence interval [CI]): 0.72 (0.46-1.10)]. Conversely, a significant increased risk was observed for individuals who carried 1 or 2 copies of the variant allele of the XRCC1 Arg399Gln polymorphism, compared with those who only harbored the wild-type allele (OR [95% CI]: 1.56 [1.01-2.45]). The above-mentioned associations were generally more pronounced among subjects with low plasma carotenoids or alpha-tocopherol (<median). Among subjects who ...Continue Reading

References

Sep 1, 1997·The Prostate·A M BakerM B Cohen
Dec 14, 1999·The American Journal of Pathology·A M De MarzoW G Nelson
Jul 31, 2001·Journal of Exposure Analysis and Environmental Epidemiology·K T Bogen, G A Keating
Jun 26, 2002·The American Journal of Clinical Nutrition·Ahmed El-SohemyHannia Campos
Jan 9, 2004·Epidemiology·Rosebud O RobertsSteven J Jacobsen
Jan 28, 2004·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Benjamin A RybickiJohn S Witte
Aug 24, 2004·Oncogene·Donald M Parkin
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Angie StoneNicholas P Lang
Jun 25, 2005·Journal of Clinical Pathology·C HughesJ O'Leary
Jul 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jamie D RitcheyAnn W Hsing
Nov 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·June M ChanEdward L Giovannucci
Dec 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert K NamSteven A Narod
Jan 2, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hiroshi HirataRajvir Dahiya
May 10, 2007·International Journal of Cancer. Journal International Du Cancer·Deliang TangBenjamin A Rybicki
Oct 12, 2007·Nutrition and Cancer·Jianjun ZhangFred F Kadlubar

❮ Previous
Next ❯

Citations

May 1, 2010·Cancer Causes & Control : CCC·Jianjun ZhangFred F Kadlubar
Jun 8, 2011·Prostate Cancer and Prostatic Diseases·B WeiZ Yan
Apr 26, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S J YunW J Kim
Feb 6, 2015·International Journal of Molecular Sciences·Rahul K LallHasan Mukhtar
Apr 3, 2012·Mutation Research·Amaya Azqueta, Andrew R Collins
Mar 3, 2010·Neuroscience Letters·Fabio CoppedèLucia Migliore
Jul 18, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Bai-Rong LiBin Song
Jun 20, 2015·Disease Markers·Kashif AliMahmood Akhtar Kayani
Jan 11, 2011·Mutation Research·Thomas B KrystonAlexandros G Georgakilas
Jan 18, 2012·Biochemical Pharmacology·Dinesh Thapa, Rita Ghosh
Aug 6, 2013·Nutrition and Cancer·Terrence M VanceOck K Chun
Dec 23, 2015·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Min Su KimSoon Chul Myung
Aug 15, 2012·Urologia Internationalis·Shimiao ZhuJianmin Wang
Apr 19, 2017·Oncotarget·Dingding ZhangBo Gong
Sep 30, 2014·The International Journal of Biological Markers·Yang ChenZengnan Mo
Apr 25, 2015·The International Journal of Biological Markers·Yang ChenZengnan Mo
Mar 22, 2014·Biomedical Reports·Cheng ZhouYue Cheng
Jul 29, 2020·Nutrients·SungEun HongEdward L Giovannucci
Oct 16, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Milan S GeybelsBas A J Verhage
May 20, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·June M ChanLorelei A Mucci
Mar 19, 2016·Chemical Research in Toxicology·Wenji LiAh-Ng Kong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics Chromatin Complexes (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin complexes and their role in cancer epigenetics.

Cancer Epigenetics and Chromatin (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin and its role in cancer epigenetics please follow this feed to learn more.