Polymorphisms in microRNA target sites of forkhead box O genes are associated with hepatocellular carcinoma

PloS One
Chao TanXiaoqiang Qiu

Abstract

The forkhead box O (FOXO) transcription factors play important roles in various cancer development including Hepatocellular Carcinoma (HCC). In this study we conducted a hospital-based case control study including 1049 cases (HCC patients) and 1052 controls (non-tumor patients) to examine whether single nucleotide polymorphisms (SNPs) within microRNA (miRNA) target sites of FOXO genes confer HCC susceptibility. A total of three miRNA target site SNPs in the 3' untranslated regions (UTR) of FOXO1 (rs17592236), FOXO3 (rs4946936) and FOXO4 (rs4503258) were analyzed. No statistically significant differences were found in genotype distribution for rs17592236, rs4946936, and rs4503258 between the HCC patient group and the tumor-free control group using single factor chi-square analysis (P>0.05). However, multivariate logistic regression analysis showed that the CT/TT genotype in rs17592236 was significantly associated with decreased risk of HCC development (P = 0.010, OR = 0.699, 95% CI: 0.526-0.927) as compared to the CC genotype in rs17592236. Additionally, a genetic interaction was found between rs17592236 and rs4503258 (P = 0.003, OR = 0.755, 95% CI: 0.628-0.908). Functional dual luciferase reporter assays verified that the rs175...Continue Reading

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Citations

Dec 3, 2015·Experimental and Molecular Pathology·Ya-Sian ChangJan-Gowth Chang
Jul 18, 2015·Redox Biology·Lars-Oliver KlotzMaria Monsalve
Sep 12, 2015·Journal of Medical Genetics·Xiaolong QiWang Ma
Jul 15, 2015·Analytical Cellular Pathology (Amsterdam)·Kenneth Maiese
Apr 17, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Jianxia MaYukun Li
Jun 9, 2016·Oncotarget·Xueren GaoJianqiong Zhang
Oct 3, 2018·Frontiers in Endocrinology·Natascha RoehlenMarissa Penna-Martinez
Feb 28, 2016·British Journal of Pharmacology·P Urbánek, L-O Klotz

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Methods Mentioned

BETA
PCR
genotyping
Assay
transfection

Software Mentioned

HaploView4
EpiData3
Haploview
miRNA Expression
SPSS

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