Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTs

PloS One
Carlos EscobarFátima Nogueira

Abstract

We report the presence of SNPs in Plasmodium falciparum K13-propeller gene in two African countries, Angola and Mozambique, where malaria is a serious public health problem. Samples were collected before and after ACT introduction as first-line treatment. In each country 50 samples collected before and 50 after ACT introduction were analysed. A total of three different mutations (R471R and R575R in Angola and V494I in Mozambique) were identified in five samples, all collected after the introduction of ACT. The R471R mutation detected in Angola has already been reported in Africa (DR-Congo and Gabon). However, the mutations R575R (Angola) and V494I (Mozambique), have never been reported. V494I is adjacent to the known K13 resistance-associated mutation Y493H, although functional analysis did not predict a deleterious effect on protein function.

References

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Citations

Feb 10, 2016·Malaria Journal·Cláudia FançonyJose Pedro Gil
Aug 4, 2015·Current Opinion in Infectious Diseases·Rick M Fairhurst
Jun 23, 2016·The New England Journal of Medicine·Didier MénardUNKNOWN KARMA Consortium
Dec 9, 2016·The American Journal of Tropical Medicine and Hygiene·Valentine DuruDidier Ménard
Oct 21, 2015·The American Journal of Tropical Medicine and Hygiene·Abebe Genetu BayihDylan R Pillai
Mar 16, 2017·Cold Spring Harbor Perspectives in Medicine·Didier Menard, Arjen Dondorp
Dec 21, 2017·Emerging Infectious Diseases·Himanshu GuptaAlfredo Mayor
Oct 28, 2015·Antimicrobial Agents and Chemotherapy·Agathe BoussaroqueBruno Pradines
Jun 3, 2015·Antimicrobial Agents and Chemotherapy·Roland A CooperPhilip J Rosenthal
Mar 27, 2021·PloS One·Ambroise AhouidiFatima Nogueira
Jun 24, 2016·Microbiology Spectrum·Rick M Fairhurst, Arjen M Dondorp

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Datasets Mentioned

BETA
KP262067

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

PROVEAN
Multalin
BLAST

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