Polymorphisms in PPARD, PPARG and APM1 associated with four types of traditional Chinese medicine constitutions

Journal of Genetics and Genomics = Yi Chuan Xue Bao
Yanrui WuChunjie Xiao

Abstract

Based on the theory of constitution of Traditional Chinese Medicine (TCM), the human population is divided into nine constitutions including one balanced constitution (Normality) and eight unbalanced constitutions (Yang-deficiency, Yin-deficiency, Phlegm-wetness, Qi-deficiency, Wetness-heat, Blood stasis, Depressed constitution, and Inherited special constitution). Different constitutions have specific metabolic features and different susceptibility to certain diseases. However, whether a genetic basis accounts for such constitution classification is yet to be determined. Here we performed a genetic study to assess the association between genetic variations of metabolic genes including PPARD, PPARG and APM1 and the constitutions. A total of 233 individuals of the Han population in China were classified into four groups, Normality, Yang-deficiency, Yin-deficiency and Phlegm-wetness with whom 23 single nucleotide polymorphisms (SNPs) in the three genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Biased distribution of PPARD rs2267669 and rs2076167, APM1 rs7627128 and rs1063539 in Yang-deficiency, PPARG Pro12Ala in Yin-deficiency and PPARD rs2076167, APM1 rs266729 and ...Continue Reading

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Citations

Jun 19, 2012·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Xiao-ling JiangZhong-ju Xiao
Jun 8, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Jianye DaiYongyu Zhang
Jul 16, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ya-Nan SongShi-Bing Su
May 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jianye DaiAiping Lu
Jan 2, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Shuang Ling, Jin-Wen Xu
Aug 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Mi Mi KoMyeong Soo Lee
Apr 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Min Ho ChaMyeong Soo Lee
Jul 2, 2011·The American Journal of Chinese Medicine·Ji WangQi Wang
Oct 21, 2015·Journal of Translational Medicine·Sun Woo HongDong-Ki Lee
Jul 26, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Linchang LiuXiangmei Chen
Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Mihui LiJingcheng Dong
Nov 27, 2021·Science China. Life Sciences

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