Polymorphisms in selected genes and analysis of their relationship with osteochondrosis in Polish sport horse breeds

Animal Genetics
M WypchłoD Lewczuk

Abstract

The aim of this research was to evaluate the polymorphisms of selected genes and to find their potential effect on the occurrence of osteochondrosis in Polish Warmbloods (sport horse breeds). The study was conducted on a group of 198 horses subjected to official performance tests. Investigated joints-fetlock, hock and stifle-were X-rayed twice, once before and again at the end of the tests (first and second examination), and on this basis the degree of disease was evaluated. Based on the results of previous research, 13 candidate genes potentially associated with the occurrence of osteochondrosis were selected and, among them, 32 polymorphisms were tested. Seven SNPs located in the MATN1, CPVL, HYAL1, XIRP2, FRZB, COL5A2 and IGF1 genes were found to be associated with occurrence of osteochondrotic lesions in different joints. These intragenic polymorphisms seem to provide valuable information about the genetic basis of osteochondrosis in sport horse breeds.

References

Oct 23, 1998·Journal of Medical Genetics·A J RichardsN P Burrows
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·John LoughlinMaripat Corr
Sep 30, 2004·Journal of Cell Science·Dirk PacholskyPeter F M van der Ven
Aug 3, 2005·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·K F StockO Distl
Jan 27, 2006·International Journal of Experimental Pathology·James HarrisSiamon Gordon
Mar 31, 2006·Arthritis and Rheumatism·N E LaneM Corr
Jun 7, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Ulrike S DiesterbeckOttmar Distl
Jul 4, 2007·Veterinary Pathology·B YtrehusS Ekman
Nov 7, 2008·BMC Musculoskeletal Disorders·Michael J MienaltowskiJames N MacLeod
Aug 16, 2011·Journal of Animal Science·S TeyssèdreA Ricard
Jul 3, 2013·The Veterinary Journal·Ottmar Distl
Apr 11, 2014·Arthritis Research & Therapy·Luigi MinafraFilippo Boniforti
Jul 17, 2016·Animal Genetics·N SevaneJ Cañon
Sep 23, 2016·Human Genome Variation·Miki WatanabeIssei Imoto

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