Polymorphisms in the 5'-upstream region of the PKCbeta gene in Japanese patients with Type 2 diabetes

Diabetic Medicine : a Journal of the British Diabetic Association
Y IkedaK Hashimoto

Abstract

Protein kinase C (PKC), a serine/threonine kinase, is known to be activated in various tissues under hyperglycaemic conditions. Notably, PKCbeta, a member of the conventional PKC group, is the predominant isoform detected in vascular tissues and could be involved in the development of diabetic vascular complications. In the present study, we investigated genetic variations in the 5'-upstream region of the PKCbeta gene to assess their possible relation to vascular complications in diabetic patients. Variations upstream from the PKCbeta gene (-1066/+256) were examined in 60 Type 2 diabetic patients using a cycle sequencing method. Screening of detected variations was performed in 204 Type 2 diabetic patients and 160 healthy controls. Five single nucleotide polymorphisms; C(-238)G, C(-287)T, A(-348)G, C(-546)G, and C(-853)T, were identified in the upstream region. The C(-287)T and A(-348)G polymorphisms were in perfect linkage disequilibrium. There were no significant differences in genotype or allele frequencies of the five polymorphisms among the diabetic patients and healthy subjects. However, both -238GG and -287CC (-348GG) homozygotes showed significantly higher frequencies of macrovascular disease compared with patients with...Continue Reading

References

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Citations

Mar 18, 2006·Current Diabetes Reports·Craig L Hanis, D Hallman
Oct 24, 2007·Molecular Genetics and Metabolism·Martin A OsterhoffAndreas F H Pfeiffer
Mar 20, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wei HuangKamal D Mehta
Apr 24, 2018·Acta Ophthalmologica·Suzanne BroadgateVictor Chong
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Apr 29, 2005·Journal of the American Society of Nephrology : JASN·Florian Lang

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