PMID: 11913728Mar 27, 2002Paper

Polymorphisms in the ABC drug transporter gene MDR1

The Pharmacogenomics Journal
U Brinkmann, M Eichelbaum

Abstract

In addition to genetically variable metabolic enzymes such as Cyp p450 proteins, blood and tissue levels of many drugs are influenced by controlled transport across compartmental boundaries. Major determinants in these transport processes are ATP-dependent efflux pumps such as P-glycoprotein and related proteins (eg MRPs), which can influence the bioavailability and CNS concentrations, as well as disposition of drugs. In addition to its recognized role in the development of multiple chemotherapy resistances, experimental evidence for the relevant influence of the MDR1 gene encoded P-glycoprotein, on the pharmacology of many other drugs has been gathered by the analyses of knockout mice, as well as in clinical studies. Recently, functional genetic polymorphisms in the MDR1 gene have been identified which influence the distribution and bioavailability of PGP substrates.

References

Nov 11, 1976·Biochimica Et Biophysica Acta·R L Juliano, V Ling
Sep 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C Cordon-CardoM R Melamed
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·F ThiebautM C Willingham
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K UedaI Pastan
Jul 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A H SchinkelP Borst
Nov 10, 1995·The Journal of Biological Chemistry·I L UrbatschA E Senior
Jan 26, 1996·The Journal of Biological Chemistry·M MüllerB Sarkadi
Jul 17, 1996·Journal of the National Cancer Institute·J van AsperenO van Tellingen
Jun 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D R FerryD J Kerr
Oct 1, 1996·Clinical and Experimental Pharmacology & Physiology·M Eichelbaum, B Evert
Oct 1, 1996·Current Opinion in Genetics & Development·M M GottesmanS V Ambudkar
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·A SparreboomO van Tellingen
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·A H SchinkelP Borst
Jan 1, 1997·Cancer Chemotherapy and Pharmacology·B I SikicG Chen
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·S DeyS V Ambudkar
Feb 7, 1998·The Journal of Clinical Investigation·C G Lee, M M Gottesman
Feb 7, 1998·The Journal of Clinical Investigation·R B KimG R Wilkinson
Mar 10, 1998·European Journal of Biochemistry·A Seelig
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J W SmitD K Meijer
Aug 8, 1998·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·J Van AsperenJ H Beijnen
Jan 1, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S P Cole, R G Deeley
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·V V RaoD Piwnica-Worms
May 20, 1999·Annual Review of Pharmacology and Toxicology·S V AmbudkarM M Gottesman
Jul 20, 1999·The Journal of Clinical Investigation·B GreinerH K Kroemer
Nov 24, 1999·Free Radical Biology & Medicine·D Keppler
Dec 3, 1999·Biochimica Et Biophysica Acta·P BorstJ Wijnholds
Mar 8, 2000·International Journal of Clinical Pharmacology and Therapeutics·M F Fromm
Mar 30, 2000·International Journal of Clinical Pharmacology and Therapeutics·M M van den Heuvel-EibrinkR Pieters
Aug 17, 2000·Journal of the National Cancer Institute·P BorstJ Wijnholds

❮ Previous
Next ❯

Citations

Apr 19, 2005·Archives of Pharmacal Research·Changjiang XuAh-Ng Tony Kong
Aug 13, 2009·Breast Cancer Research and Treatment·UNKNOWN MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk
Jul 14, 2010·Breast Cancer Research and Treatment·Pei-Hua LuMin-Bin Chen
Jan 22, 2003·Advanced Drug Delivery Reviews·Klaas Nico FaberPeter L M Jansen
May 6, 2003·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Alex SparreboomWilliam D Figg
Mar 11, 2010·Pharmacogenetics and Genomics·Laura M HodgesRuss B Altman
Mar 30, 2004·Antimicrobial Agents and Chemotherapy·Sanjay U C SankatsingJan M Prins
Oct 29, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Isa CavacoVera Ribeiro
Nov 11, 2003·Clinical Pharmacokinetics·Susan E TettAndrew J McLachlan
Feb 10, 2010·Annals of Indian Academy of Neurology·Manna Jose, Sanjeev V Thomas
Jul 3, 2010·The American Journal of Tropical Medicine and Hygiene·Catherine BourguinatTimothy G Geary
Jul 6, 2013·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mortaza J BonyadiManouchehr Khoshbaten
Aug 4, 2007·Journal of Cancer Research and Clinical Oncology·Darinka Todorova PetrovaNicolas von Ahsen
Dec 11, 2014·Pharmacogenomics·James M Stevenson, Jeffrey R Bishop
Oct 11, 2014·Thrombosis Research·Marco FerrariWalter Ageno
Feb 25, 2014·Expert Opinion on Drug Discovery·Daniel SaaberStephan Reichl
Jun 2, 2007·Expert Opinion on Drug Metabolism & Toxicology·Zhongqiu Liu, Ming Hu
Oct 1, 2005·Cancer Investigation·Isa E L M KuppensJ H M Schellens
Sep 22, 2010·Molecular Genetics and Metabolism·Mayumi SaekiMasahiro Tohkin
May 12, 2009·Molecular Aspects of Medicine·Alessandra di MasiMaria Marino
Jan 22, 2013·British Journal of Clinical Pharmacology·Christian FriedrichHans-Juergen Woerle
Jul 14, 2005·Progress in Neurobiology·Wolfgang Löscher, Heidrun Potschka
Dec 28, 2004·Drug Metabolism and Pharmacokinetics·Noriko Kose MatsunagaEmi Nakashima
Apr 7, 2015·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Manzoor A Malik
Jan 24, 2015·Pharmacogenomics·Liliane GschwindJules Alexandre Desmeules
May 12, 2011·Drug Metabolism and Drug Interactions·Alberto Lazarowski, Liliana Czornyj

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.