Polymorphisms in the alpha1A-adrenoceptor gene do not modify the short- and long-term efficacy of alpha1-adrenoceptor antagonists in the treatment of benign prostatic hyperplasia

BJU International
Chaidir A MochtarLambertus A L M Kiemeney

Abstract

OBJECTIVE To determine whether a common single nucleotide polymorphism (SNP) in the ADRA1A gene encoding the alpha(1A)-adrenoceptor modifies the short- and long-term efficacy of alpha(1)-adrenoceptor antagonists in the treatment of benign prostatic hyperplasia (BPH). PATIENTS AND METHODS For 254 patients with BPH and/or lower urinary tract symptoms who received alpha(1)-adrenergic antagonists for > or = 3 months, the ADRA1A genotype at position 1475 of the coding region was determined. The patients' short-term response to treatment was determined for four outcome measures, i.e. the International Prostate Symptom Score (IPSS), the IPSS quality-of-life score, peak urinary flow rate, and obstruction grade, stratified by genotype. Eventual BPH-related invasive therapy was used as the outcome for assessing the long-term response to treatment. Genetic variants at positions 834, 896, 898 and 1831 were too rare to be considered in the analysis. RESULTS There were no significant differences for the genotype strata in three of the four outcome measures. Patients with the CC genotype responded significantly better in quality-of-life perception than patients with the CT or TT genotype. There were also no significant differences in the risk...Continue Reading

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Citations

Jan 10, 2009·Nature Clinical Practice. Urology·Yoshiyuki KojimaKenjiro Kohri
Nov 4, 2006·Biochimica Et Biophysica Acta·Paul A InselMartin C Michel
Aug 19, 2007·Neurourology and Urodynamics·K-E Andersson
Apr 16, 2008·BJU International·Rituraj KonwarHemant Kumar Bid
Dec 17, 2008·Pharmacological Reviews·Dieter Rosskopf, Martin C Michel
Aug 9, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Xiaoqiang QianJun Qi
Dec 16, 2011·The American Journal of Clinical Nutrition·Giulia RendaRaffaele De Caterina
Jun 15, 2014·Pharmacological Reviews·Andrea Ahles, Stefan Engelhardt

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