Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patients

European Archives of Psychiatry and Clinical Neuroscience
P ZillB Bondy

Abstract

Two recently described polymorphisms in the promoter region of the apolipoprotein E (APOE), the -491A/T and Th1/E47csT/G polymorphism, have been suggested to be associated with an increased risk for Alzheimer's disease (AD) independent from the APOE epsilon 4 carrier status. We studied the association between the APOE epsilon 4 polymorphism and the -491A/T and Th1E47csT/G polymorphisms in a sample of 118 healthy, non-demented controls and 239 consecutively recruited gerontopsychiatric patients diagnosed as: Alzheimer's disease (N = 89), age mild cognitive impairment (N = 32), memory complainers without any cognitive deficit (N = 54) and depression/other psychiatric disorders (N = 64), to test whether the investigated polymorphisms have a high enough selectivity and specificity to distinguish between the different gerontopsychiatric disorders or to differentiate AD genetically from other forms of dementia, respectively. Also a possible association with the APOE epsilon 4 polymorphism was examined. We found a statistically significant association between the APOE epsilon 4 allele and Alzheimer's disease (p = 0.0001) and age associated memory impairment (p = 0.006). Our study failed to show an association between the promoter poly...Continue Reading

Citations

Jun 6, 2003·Brain Research Bulletin·A RocchiL Murri
Jun 30, 2009·European Psychiatry : the Journal of the Association of European Psychiatrists·R HeunS G Riedel-Heller
Nov 10, 2004·Cranio : the Journal of Craniomandibular Practice·John S DuPont

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