PMID: 16520538Mar 8, 2006Paper

Polymorphisms in the canine glutamate transporter-1 gene: identification and variation among five dog breeds

The Journal of Veterinary Medical Science
Niwako OgataYuji Mori

Abstract

Excitatory amino acid transporters (EAATs) are important for terminating glutamatergic neurotransmission and protect central nervous system (CNS) neurons from glutamatergic excitotoxicity. We selected these genes as targets that may relate to canine behavioral traits. After screening four EAAT genes (glutamate transporter-1; GLT-1, excitatory amino acid transporter 4; EAAT4, excitatory amino acid carrier; EAAC1, glutamate/aspartate transporter; GLAST) for single nucleotide polymorphisms (SNPs), we identified two silent SNPs (C129T and T471C) in the GLT-1 gene. We genotyped 193 dogs of 5 breeds and found significant variation among breeds in these two SNPs in GLT-1. The C129T polymorphism was not observed in Malteses and Miniature Schnauzers. These results suggest that polymorphisms in the GLT-1 gene may be useful markers for examining how the genetic background relates to the behavioral traits of dogs.

References

Jul 1, 1995·Annals of Neurology·J D RothsteinR W Kuncl
Oct 1, 1995·The European Journal of Neuroscience·L M LevyN C Danbolt
May 20, 1999·Annual Review of Pharmacology and Toxicology·R P Seal, S G Amara
Oct 20, 2001·The Journal of Veterinary Medical Science·K SatoK Kagota
Mar 20, 2004·The Journal of Veterinary Medical Science·Koji MasudaYuji Mori
Apr 2, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Veerle BerginkHerman G M Westenberg

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Citations

May 11, 2013·Molecular Biology and Evolution·Yan LiYa-Ping Zhang
Feb 19, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Miho Inoue-Murayama
Jan 9, 2008·American Journal of Human Genetics·Tyrone C Spady, Elaine A Ostrander
Nov 5, 2008·The Journal of Veterinary Medical Science·Fumihiro KanekoYuji Mori

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