Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction

The New England Journal of Medicine
L IacovielloM Benedetta Donati

Abstract

High blood levels of coagulation factor VII are associated with a risk of ischemic vascular disease. Although factor VII levels may be genetically determined, the relation between genetic polymorphisms of factor VII, factor VII blood levels, and the risk of myocardial infarction has not been established. We performed a case-control study of 165 patients with familial myocardial infarction (mean [+/-SD] age, 55+/-9 years) and 225 controls without a personal or family history of cardiovascular disease (mean age, 56+/-8 years). The polymorphisms involving R353Q and hypervariable region 4 of the factor VII gene were studied. Factor VII clotting activity and antigen levels were also measured. Patients with the QQ or H7H7 genotype had a decreased risk of myocardial infarction (odds ratios, 0.08 [95 percent confidence interval, 0.01 to 0.9] and 0.22 [95 percent confidence interval, 0.08 to 0.63], respectively). For the R353Q polymorphism, the RR genotype was associated with the highest risk, followed by the RQ genotype and then by the QQ genotype (P<0.001). For the polymorphism involving hypervariable region 4, the combined H7H5 and H6H5 genotypes were associated with the highest risk, followed in descending order by the H6H6, H6H7, a...Continue Reading

References

Mar 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·C J HoffmanM B Hultin
May 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·F GreenS Humphries
Aug 25, 1991·Nucleic Acids Research·G MarchettiF Bernardi
Mar 1, 1989·International Journal of Epidemiology·P Froggatt
Feb 1, 1994·Human Molecular Genetics·P de KnijffC Kluft
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J HeinrichJ van de Loo
Jan 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·J R Guyton, K F Klemp
Jan 19, 1996·The Journal of Biological Chemistry·E S PollakK A High
Feb 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·X L WangD E Wilcken
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·M P de MaatC Kluft

❮ Previous
Next ❯

Citations

Dec 14, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Julian C Knight
Nov 18, 2005·Human Genetics·Maria Sabater-LlealFrancesc Calafell
Aug 31, 2012·Journal of Thrombosis and Thrombolysis·Sonia Ben-Hadj-KhalifaWassim Y Almawi
Jun 19, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Roberto TrottaLicia Iacoviello
Mar 26, 2004·Thrombosis Research·Giovanni de GaetanoMaria Benedetta Donati
Nov 25, 2000·The American Journal of Cardiology·L F WateletD Ryan
Mar 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Georg Endler, Christine Mannhalter
Feb 28, 2002·AIDS Treatment News
Dec 17, 2002·Atherosclerosis·Pierre-Yves ScarabinUNKNOWN Prospective Epidemiological Study of Myocardial Infarction
Nov 18, 2000·Journal of the American College of Cardiology·P M MrozikiewiczK Stangl
Jun 6, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Lucy A Norris
Jul 25, 2000·British Journal of Clinical Pharmacology·M W Lunnon, M Braddock
Nov 11, 1999·British Journal of Haematology·M HunaultK A Bauer
Dec 12, 2001·British Journal of Haematology·R F Franco, P H Reitsma
Dec 19, 2002·European Journal of Clinical Investigation·S KakkoM J Savolainen
Jan 8, 1998·The New England Journal of Medicine·N Rosenthal, R S Schwartz
May 30, 1998·The New England Journal of Medicine·D AltshulerE Lander
Dec 13, 2002·The New England Journal of Medicine·Yoshiji YamadaMitsuhiro Yokota
Jan 23, 1999·Current Opinion in Rheumatology·T JuvonenM J Savolainen
Jun 11, 1999·Critical Care Medicine·G Santis, T W Evans
Nov 11, 1999·Current Opinion in Lipidology·R P Tracy
Nov 11, 1999·Current Opinion in Lipidology·T G DeLoughery
Feb 24, 2001·Molecular Pathology : MP·T C SykesD Mosquera
Apr 12, 2011·Lipids in Health and Disease·Juan Criado-GarcíaUNKNOWN Spanish Group for the Study of Familiar Hypercholesterolemia
Jun 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Masakazu OgawaChuwa Tei
Sep 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshiji Yamada
Jan 23, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·C Ferrer-Antunes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.